ChemicalBook CAS DataBase List Tris (O-TBDMS)3

Tris (O-TBDMS)3 synthesis

2synthesis methods

Product Name:Tris (O-TBDMS)3
CAS Number:102522-47-4
Molecular formula:C22H53NO3Si3
Molecular Weight:463.92

18162-48-6 Synthesis

18162-48-6
664 suppliers
$9.00/5g

77-86-1 Synthesis

77-86-1
970 suppliers
$5.00/25g

102522-47-4
22 suppliers
$160.00/1g

Yield:102522-47-4 98%

Reaction Conditions:

with 1H-imidazole in N,N-dimethyl-formamide at 20; for 1 h;

Steps:

2.1.A

A) Synthesis of tris-(/ert-butyldimethylsilyloxymethyl)aminomethane, 2 Butyldimethylsilyl chloride (6.7g, 44.6mmol) and imidazole (6.3g, 92.9mmol) were dissolved in DMF (5mL). Tris(hydroxymethyl)methyl amine, 1 (1.5g, 12.4mmol) was added and the mixture stirred at room temperature for 1 hour. The product was washed with H₂O, extracted with DCM, dried over anhydrous MgSO₄ and filtered. Solvent was removed under reduced pressure to give a white powder (5.6g, 12.1mmol, 98%): ¹H NMR (CDCl₃) δ: 3.4 (s, 6H), 0.85 (s, 27H), 0.0 (s, 18H). ¹³C NMR (CDCl₃) δ: 64.5, 57.1, 26.3, 17.9. LRMS (ES+) m/z 464.5 [100, (M+H⁺)].

References:

WO2009/50483,2009,A1 Location in patent:Page/Page column 26

18162-48-6 Synthesis

18162-48-6
664 suppliers
$9.00/5g

102522-47-4
22 suppliers
$160.00/1g

References