Darunavir ethanolate synthesis
- Product Name:Darunavir ethanolate
- CAS Number:635728-49-3
- Molecular formula:C29H43N3O8S
- Molecular Weight:593.74
191226-98-9
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogen; triethanolamine / palladium 10% on activated carbon / methanol / 2 h / 40 - 45 °C
2.1: hydrogenchloride; water / 2 h / Reflux
3.1: 1-methyl-pyrrolidin-2-one / 10 h / -4 - 30 °C
3.2: 1 h / 45 - 50 °C
References:
US2012/251826,2012,A1