Darunavir ethanolate
- CAS No.
- 635728-49-3
- Chemical Name:
- Darunavir ethanolate
- Synonyms
- Darunavir ethanolate;Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1);To the drug;Unii-33o78xf0bw;[14C]-Darunavir ethanolate;Darunavir Ethanolate (100 mg);Darunavir Ethanolate(Prezista);Darunavir hemiethanolate salt;Darunavir Ethanolate (DRV, Prezista);Darunavir(TMC-114,UIC 94017) Ethanolate
- CBNumber:
- CB32496602
- Molecular Formula:
- C29H43N3O8S
- Molecular Weight:
- 593.74
- MDL Number:
- MFCD18251642
- MOL File:
- 635728-49-3.mol
Melting point | 98-100°C |
---|---|
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | White |
FDA UNII | 33O78XF0BW |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 29334900 |
Darunavir ethanolate price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | D193520 | DarunavirEthanolate | 635728-49-3 | 5mg | $150 | 2021-12-16 | Buy |
Usbiological | 163597 | Darunavir Ethanolate | 635728-49-3 | 5mg | $460 | 2021-12-16 | Buy |
TRC | D193520 | DarunavirEthanolate | 635728-49-3 | 50mg | $770 | 2021-12-16 | Buy |
ChemScene | CS-0750 | DarunavirEthanolate 99.92% | 635728-49-3 | 100mg | $500 | 2021-12-16 | Buy |
Biosynth Carbosynth | FD64995 | Darunavir Ethanolate | 635728-49-3 | 500mg | $175 | 2021-12-16 | Buy |
Darunavir ethanolate Chemical Properties,Uses,Production
Uses
Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
Uses
Darunavir Ethanolate(Prezista) is an inhibitor of HIV protease. [1] Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati
Biological Activity
darunavir ethanolate is a nonpeptidic hiv protease inhibitor approved for the treatment of hiv infection[1].transepithelial transport of darunavir in caco-2 cell monolayers is 2-fold greater in the basal-to-apical direction compared to that in the opposite direction. in l-mdr1 cell, darunavir (121 mm) inhibits p-glycoprotein-mediated efflux of calcein-acetoxymethyl ester[1].darunavir is effective against wild-type and pi-resistant hiv, and has a low oral bioavailability (37%). when used in combination with ritonavir, bioavailability can be increased to 82%[2].[1]. fujimoto h, higuchi m, watanabe h, et al. p-glycoprotein mediates efflux transport of darunavir in human intestinal caco-2 and abcb1 gene-transfected renal llc-pk1 cell lines. biological & pharmaceutical bulletin, 2009, 32(9): 1588-1593.[2]. bhalekar mr, et al. in-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. drug deliv, 2016, 23(7): 2581-2586.
![191226-98-9](/CAS/GIF/191226-98-9.gif)
![635728-49-3](/CAS/20180713/GIF/635728-49-3.gif)
Darunavir ethanolate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
Related articles
- An anti-HIV drug (Darunavir ethanolate) in COVID-19 treatment
- Darunavir ethanolate: the drug approved for the treatment of HIV and also hypothesised to inhibit the protease of SARS-CoV-2.
- Oct 13,2023
View Lastest Price from Darunavir ethanolate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2024-08-22 | Darunavir ethanolate
635728-49-3
|
US $0.00 / Kg/Bag | 2Kg/Bag | 0.0099 | 20 tons | Sinoway Industrial co., ltd. | |
![]() |
2024-08-20 | Unii-33o78xf0bw
635728-49-3
|
US $63.00 / g | 1g | 98% | 100kg | Baoji Guokang Bio-Technology Co., Ltd. | |
![]() |
2021-07-13 | Unii-33o78xf0bw
635728-49-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Darunavir ethanolate
635728-49-3
- US $0.00 / Kg/Bag
- 0.0099
- Sinoway Industrial co., ltd.
-
- Unii-33o78xf0bw
635728-49-3
- US $63.00 / g
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- Unii-33o78xf0bw
635728-49-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
635728-49-3(Darunavir ethanolate)Related Search:
1of4