Warfarin synthesis

8synthesis methods

Product Name:Warfarin
CAS Number:81-81-2
Molecular formula:C19H16O4
Molecular Weight:308.33

Warfarin, 3-(α-acetonylbenzyl)-4-hydroxycoumarin (24.1.10), is synthesized via Michael reaction by attaching 4-hydroxycoumarin (24.1.7) to benzalacetone in the presence of pyridine.

1076-38-6
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60-12-8 Synthesis

60-12-8
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516-06-3 Synthesis

516-06-3
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81-81-2
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$18.00/1g

Yield:81-81-2 84%

Reaction Conditions:

in dimethyl sulfoxide at 20; for 16 h;

Steps:

1.1.1 1. Synthesis of Compound 3
4-hydroxycoumarin (compound 1, 1.62 g, 10 mmol),Benzylmethanol (Compound 2, 1.46 mg, 10 mmol)A solution of DL-valine (580 mg, 5 mmol) in DMSO (20 mL) was stirred at 20 ° C for 16 h.120 mL of water was added to the reaction mixture.The reaction mixture was extracted three times with ethyl acetate (100 mL).The combined organic phases were washed with 100 mL of water and brine (100 mL)The solvent was recovered on a rotary evaporator to give a white residue (3.3 g).The residue was separated by silica gel column chromatography ( petroleum ether: ethyl acetate = 4:1, v/v)A white powder (2.60 g, 84%) was obtained as Compound 3.

References:

China Agricultural University;Shen Jianzhong;Wang Zhanhui;Jiang Haiyang;Wen Kai;Yu Wenbo;Yu Xuezhi;Li Hongfang;Duan Changfei;Shi Weimin;Zhang Suxia CN109824645, 2019, A Location in patent:Paragraph 0060; 0061-0063

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1076-38-6
534 suppliers
$24.00/100 g

122-57-6 Synthesis