Zaleplon synthesis
- Product Name:Zaleplon
- CAS Number:151319-34-5
- Molecular formula:C17H15N5O
- Molecular Weight:305.33
96605-66-2
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$16.00/1g
16617-46-2
483 suppliers
$6.00/5g
151319-34-5
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$65.00/1mg
Yield:151319-34-5 100 %Chromat.
Reaction Conditions:
with heptafluorobutyric Acid in water;butanone at 20;Product distribution / selectivity;
Steps:
2
Example 2; [0102] N- [3- [3- (dimethylamino)-l-oxo-2-propenyl] phenyl] -N-ethylacetamide (1.3 g), 3- amino-4-cyanopyrazole (0.54 g) were weighed into a 50 mL Erlenmeyer flask containing a magnetic stir bar. Water (17 mL), 2-butanone (17 mL) and of heptafluorobutyric acid (0.5 mL) were added to form the two phases. The two-phase mixture was stirred vigorously at room temperature and sampled for HPLC (50 gL each phase/100 mL methanol) at 30 minutes, 60 minutes, 90 minutes, and after stirring overnight. The area percents for zaleplon were 55. 0 %, 77.5 %, 86.7 % and 100 % at the stated time intervals, respectively.
References:
MALLINCKRODT INC. WO2005/70931, 2005, A1 Location in patent:Page/Page column 12
98-86-2
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151319-34-5
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$65.00/1mg
121-89-1
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$5.00/10g
151319-34-5
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$65.00/1mg
7463-31-2
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$12.00/5g
151319-34-5
3 suppliers
$65.00/1mg
96605-66-2
193 suppliers
$16.00/1g
16617-46-2
483 suppliers
$6.00/5g
478081-98-0
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151319-34-5
3 suppliers
$65.00/1mg