![](/CAS/GIF/16617-46-2.gif)
3-Amino-4-pyrazolecarbonitrile synthesis
- Product Name:3-Amino-4-pyrazolecarbonitrile
- CAS Number:16617-46-2
- Molecular formula:C4H4N4
- Molecular Weight:108.1
![Triethyl orthoformate](/CAS/GIF/122-51-0.gif)
122-51-0
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$10.00/5ml
![Malononitrile](/CAS/GIF/109-77-3.gif)
109-77-3
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$10.00/5g
![3-Amino-4-pyrazolecarbonitrile](/CAS/GIF/16617-46-2.gif)
16617-46-2
482 suppliers
$6.00/5g
Yield:16617-46-2 72%
Reaction Conditions:
Stage #1:orthoformic acid triethyl ester;malononitrile with acetic anhydride at 115; for 2 h;
Stage #2: with hydrazine hydrate at 18 - 30; for 18.6667 h;
Steps:
Amino-1H-pyrazole-4-carbonitrile
Add malononitrile (16.5 g, 0.25 mol), triethyl orthoformate (38 g, 0.29 mol) and acetic anhydride (55 g,0.54 mol) to a 1 L three-necked flask, slowly heat to 115 °C, reflux reaction for 2 h .The temperature of the mixture was lowered to 20 °C,hydrazine hydrate (15.5 g, 0.31 mol) was added dropwiseover 40minutes, and the temperature was maintained at 18-22 °C.The reaction was then carried out at 20-30 ° C for 18 h.Thereaction wasmonitoredbyTLC, neutralized with a sodium hydroxide aqueous solution (36 g of sodium hydroxide in 72 ml of water) at 25 °C to obtain a prize mixture, and the mixture washeated and azeotropically distilled to collect 45 ml fractions.This fraction was cooled at 0 to 5 ° C for 1.5 h, and a pale brown solid was collected,rinsedwithcold water and dried to give product (19.2 g, 72% yield).
References:
Jiangnan University;Tang Chunlei;Cao Kai;Zhao Hui;Hu Xiaoxia;Fan Weizheng;Feng Bonian;Liao Hanyue CN108484613, 2018, A Location in patent:Paragraph 0044; 0045; 0046
![Ethoxymethylenemalononitrile](/CAS/GIF/123-06-8.gif)
123-06-8
348 suppliers
$14.14/1gm:
![3-Amino-4-pyrazolecarbonitrile](/CAS/GIF/16617-46-2.gif)
16617-46-2
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$6.00/5g
![Hydrazine hydrate](/CAS/GIF/7803-57-8.gif)
7803-57-8
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$20.10/50g
![Ethoxymethylenemalononitrile](/CAS/GIF/123-06-8.gif)
123-06-8
348 suppliers
$14.14/1gm:
![3-Amino-4-pyrazolecarbonitrile](/CAS/GIF/16617-46-2.gif)
16617-46-2
482 suppliers
$6.00/5g
![2-(Chloromethylidene)propanedinitrile](/CAS/20210111/GIF/10472-09-0.gif)
10472-09-0
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![3-Amino-4-pyrazolecarbonitrile](/CAS/GIF/16617-46-2.gif)
16617-46-2
482 suppliers
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![(methoxymethylene)malononitrile](/CAS/GIF/672-81-1.gif)
672-81-1
24 suppliers
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![3-Amino-4-pyrazolecarbonitrile](/CAS/GIF/16617-46-2.gif)
16617-46-2
482 suppliers
$6.00/5g