ChemicalBook CAS DataBase List Zileuton Impurity 2

Zileuton Impurity 2 synthesis

5synthesis methods

Product Name:Zileuton Impurity 2
CAS Number:1026256-93-8
Molecular formula:C17H15NO3S
Molecular Weight:313.37

Benzo[b]thiophene-2-methanol, α-methyl-, 2-acetate

26929-23-7
1 suppliers
inquiry

38064-07-2
23 suppliers
$76.00/1g

1026256-93-8
11 suppliers
inquiry

Yield:1026256-93-8 85%

Reaction Conditions:

with boron trifluoride diethyl etherate at 5 - 30; for 2 h;

Steps:

5 Preparation of phenyl 1-(benzo[b]thiophen-2-yl)ethyl(hydroxyl) carbamate (V

The organic phase obtained in Example- 2, phenyl N-hydroxy carbamate (141.7 gm) was added and cooled to 5-10° C. Boron trifluoride dietherate (18.75 gm) was slowly added to the mixture at 25-30° C. for 2 hrs. The progress of the reaction was monitored by HPLC. After completion of the reaction, water (900 ml) was added to the reaction mass and stirred. The contents were cooled to 0-5° C., filtered, washed with cyclohexane and dried. % Yield: 85%

References:

US2016/376251,2016,A1 Location in patent:Paragraph 0114