4-하이드록시벤조 산(
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4-하이드록시벤조 산( 속성
- 녹는점
- 213-217 °C (lit.)
- 끓는 점
- 213.5°C (rough estimate)
- 밀도
- 1,46 g/cm3
- 증기압
- 0Pa at 20℃
- 굴절률
- 1.4600 (estimate)
- 인화점
- 199 °C
- 저장 조건
- Store below +30°C.
- 용해도
- 메탄올: 용해성 5%, 투명하거나 약간 흐릿함, 무색 내지 희미한 노란색
- 산도 계수 (pKa)
- 4.48(at 19℃)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 아이보리까지
- 수소이온지수(pH)
- 3.3 (1g/l, H2O, 20℃)
- 냄새
- 100.00%에서. 페놀 너트
- ?? ??
- 페놀성
- 수용성
- 5g/L(20℃)
- Merck
- 14,4812
- JECFA Number
- 957
- BRN
- 970950
- InChIKey
- FJKROLUGYXJWQN-UHFFFAOYSA-N
- LogP
- 0.878 at 22℃
- CAS 데이터베이스
- 99-96-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36-36/37/38 | ||
안전지침서 | 26-37/39-36 | ||
WGK 독일 | 1 | ||
RTECS 번호 | DH1925000 | ||
자연 발화 온도 | >250 °C | ||
TSCA | Yes | ||
HS 번호 | 29182930 | ||
유해 물질 데이터 | 99-96-7(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: > 5000 mg/kg | ||
기존화학 물질 | KE-20369 |
4-하이드록시벤조 산( C화학적 특성, 용도, 생산
개요
4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid or PHBA, is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohol and acetone. It is isomeric with salicylic acid (2-hydroxybenzoic acid), a forerunner to aspirin, and 3-hydroxybenzoic acid. The esters of 4-hydroxybenzoic acid, also called parabens, are widely used as preservatives in cosmetics and some ophthalmic solutions.화학적 성질
4-Hydroxybenzoic acid is an odorless white crystalline astringent powder. In pure form, it imparts a sweetish taste at first, which quickly becomes acrid and disagreeable출처
4-Hydroxybenzoic acid is a phenolic acid that has been found in a variety of fruit peels and leaves. It can be found naturally in coconut. It is one of the main catechins metabolites found in humans after consumption of green tea infusions. It is also found in wine, in vanilla, in Macrotyloma uniflorum (horse gram), carob and in Phyllanthus acidus (Otaheite gooseberry).용도
4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4'-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.제조 방법
Prepared from p-bromophenol or p-hydroxybenzaldehyde, or from saponification of methyl salicylate, a major component of oil of wintergreen.In 1947, H. Gilman and C. E. Arntzen at Iowa State College (Ames) reported the synthesis of 4-HBA from 4-hydroxybenzaldehyde. Several other preparation methods were developed since then. Today it is produced commercially via the Kolbe–Schmitt reaction, which originated in the mid-1800s. Potassium phenoxide and CO2 are heated under pressure; the reaction mixture is then acidified to obtain the product 4-Hydroxybenzoic acid. (Oddly, if the sodium salt is used, the product is 2-hydroxybenzoic acid, or salicylic acid.)
Org. Synth. 1934, 14, 48
DOI: 10.15227/orgsyn.014.0048
정의
ChEBI: 4-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring. It has a role as a plant metabolite and an algal metabolite. It is a conjugate acid of a 4-hydroxybenzoate.주요 응용
4-Hydroxybenzoic acid can be used as a starting material to synthesize organic intermediates such as 4-acetoxybenzoic acid and 4-hydroxy-3,5-diiodobenzoic acid.4-Hydroxybenzoic acid is used as an intermediate for dyes, antiseptics and active pharmaceutical ingredients. It is also used as a food preservative, corrosion inhibitor, anti-oxidant and an emulsifier. It reacts with 6-hydroxynaphthalene-2-carboxylic acid to prepare aromatic polyester called Vectran fiber. It acts as a precursor to prepare p-hydroxyphenylbenzoate, p-acetoxybenzoyl chloride and 4,4′-dihydroxybenzophenone. Further, it is used in paint additives, coating additives, processing aids, electrical and electronic products. In addition to this, it acts as a preservative in cosmetics and some ophthalmic solutions.
일반 설명
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.Purification Methods
Crystallise the hydroxyacid from water. [Beilstein 10 IV 345.]4-하이드록시벤조 산( 준비 용품 및 원자재
원자재
사카린
수산화칼륨
페놀
Dipotassium rabdosiin Rabdosiin
Potassium hydroxide solution
파라-톨루엔설폰일 염화물
포타슘페녹사이드
황산칼륨
Methyl 4-bromobenzoate
4-Iodobenzoic acid
4-(3-부테닐록시)벤조산
4-벤질록시벤조산
준비 용품
4-하이드록시벤조 산( 공급 업체
글로벌( 878)공급 업체
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