p-아니식애씨드
|
|
p-아니식애씨드 속성
- 녹는점
- 182-185 °C(lit.)
- 끓는 점
- 275 °C
- 밀도
- 1.385
- 증기압
- 0.001Pa at 25℃
- 굴절률
- 1.571-1.576
- 인화점
- 185 °C
- 저장 조건
- Store below +30°C.
- 용해도
- H2O: 용해성2500부
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.50(at 25℃)
- 색상
- 흰색에서 약간 회색-베이지색
- 수소이온지수(pH)
- 3-4 (0.3g/l, H2O, 20℃)
- 냄새
- 디프로필렌 글리콜 중 10.00%. 희미한 썩은 냄새
- ?? ??
- 동물
- 수용성
- 20°C에서 물에 용해됨 0.3g/L. 알코올, 에틸 아세테이트 및 에테르에 용해됩니다.
- Merck
- 14,666
- JECFA Number
- 883
- BRN
- 508910
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N
- LogP
- 1.96
- CAS 데이터베이스
- 100-09-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-22 | ||
안전지침서 | 26-36-24/25 | ||
WGK 독일 | 1 | ||
RTECS 번호 | BZ4395000 | ||
자연 발화 온도 | 185 °C | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29189090 | ||
독성 | LD50 orally in Rabbit: > 5000 mg/kg |
p-아니식애씨드 C화학적 특성, 용도, 생산
개요
P-Anisic acid, also known as 4-Methoxybenzoic acid or draconic acid, is an organic acid that has a sweet flavor. It is one of the isomers of anisic acid, including m-anisic acid and o-anisic acid. The term "anisic acid" often refers to this form specifically. P-anisic acid is produced through the oxidation of p-cresyl-methyl ether.화학적 성질
It appears as a colorless needle crystal at room temperature. It is soluble in ethanol, ether, and chloroform, and only slightly soluble in hot water. It remains insoluble in cold water. It is used as an intermediate for aniracetam, as well as a preservative and fragrance.용도
4-Methoxybenzoic acid (p-Anisic acid) is used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds.제조 방법
To obtain 4-Methoxybenzoic acid, the mole ratio of cobalt and manganese is modified and p-methoxy toluene is reacted with oxygen or an oxygen-containing gas in the presence of acetic acid. The following is the experimental procedure:1. Using n-hexyl bromide, tri (n-hexyl) amine, para-methoxy toluene with cobalt chloride hexahydrate in about 9h;2. By a catalytic oxidation process using p-methoxy toluene and propionic acid over a catalyst comprising of CoBr2.6H2O and MnBr2.4H2O with a reaction time of 20h;
3. Through changing the mole ratio of cobalt and manganese, using p-methoxy toluene with oxygen or oxygen containing gas in the presence of acetic acid to obtain the product.
정의
ChEBI: 4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate.일반 설명
4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069. It is effective in clearing congestion in the lungs and the respiratory tracts in conditions like asthma or bronchitis.Biochem/physiol Actions
The cytochrome P450 enzyme CYP199A4, a heme-dependent cytochrome P450 (CYP) monooxygenase enzyme, can efficiently demethylate 4-methoxybenzoic acid. Mechanistically, O-demethylation of 4-methoxybenzoic acid occurs via hydrogen abstraction by Compound I, followed by oxygen rebound to give the hydroxylated hemiacetal which spontaneously decomposes to yield 4-hydroxybenzoic acid and formaldehyde[5].Safety Profile
Poison by subcutaneous route.When heated to decomposition it emits acrid smoke andirritating vapors.Purification Methods
Crystallise p-anisic acid from EtOH, water, EtOH/water or toluene. The S-benzylisothiuronium salt has m 189o (from EtOH). [Beilstein 10 II 91, 10 III 280, 10 IV 346.]p-아니식애씨드 준비 용품 및 원자재
원자재
준비 용품
p-아니식애씨드 공급 업체
글로벌( 730)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 984 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 3003 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 3001 | 58 |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 |
hanson@sdhanjiang.com | China | 889 | 58 |
Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 |
Ethan@dornechem.com | China | 300 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-199-55145978 +8619955145978 |
sales8@anhuiyiao.com | China | 253 | 58 |
Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |