替拉鲁替尼
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- CAS号:
- 1351636-18-4
- 英文名:
- Btk Kinase inhibitor
- 英文别名:
- ONO-BKT;ONO BTK;Tirabrutinib;TIRABRUTINIB;GS-4059;Btk Kinase inhibitor;ONO-4059(Tirabrutinib);Tirabrutinib free base;Isoleucine Impurity 18;Tirabrutinib (ONO-4059);ONO-4059;ONO 4059;ONO4059
- 中文名:
- 替拉鲁替尼
- 中文别名:
- 替拉鲁替尼;化合物TIRABRUTINIB;(R)-6-氨基-9-(1-(丁-2-炔酰基)吡咯烷-3-基)-7-(4-苯氧基苯基)-7H-嘌呤-8(9H)-酮;(R)-6-氨基-9-(1-(丁-2-炔酰基)吡咯烷-3-基)-7-(4-苯氧基苯基)-7,9-二氢-8H-嘌呤-8-酮
- CBNumber:
- CB02716154
- 分子式:
- C25H22N6O3
- 分子量:
- 454.48
- MOL File:
- 1351636-18-4.mol
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替拉鲁替尼化学性质
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沸点:
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672.0±65.0 °C(Predicted)
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密度:
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1.412±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:65.0(Max Conc. mg/mL);143.02(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.66(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);66.01(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);2.2(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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3.16±0.20(Predicted)
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替拉鲁替尼性质、用途与生产工艺
用途
一种有效的口服活性的BTK(布鲁顿酪氨酸激酶)抑制剂, IC50:2.2nM。Tirabrutinib is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. As a result, this agent may inhibit the proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
替拉鲁替尼
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15771 | Tirabrutinib | | 1 mg | 272元 |
2024/04/30 | HY-15771 | 替拉鲁替尼 Tirabrutinib | 1351636-18-4 | 5mg | 600元 |
1351636-18-4, 替拉鲁替尼 相关搜索:
- 标准品
- 抑制剂
- (R)-6-氨基-9-(1-(丁-2-炔酰基)吡咯烷-3-基)-7-(4-苯氧基苯基)-7,9-二氢-8H-嘌呤-8-酮
- 化合物TIRABRUTINIB
- (R)-6-氨基-9-(1-(丁-2-炔酰基)吡咯烷-3-基)-7-(4-苯氧基苯基)-7H-嘌呤-8(9H)-酮
- 替拉鲁替尼
- 1351636-18-4
- Isoleucine Impurity 18
- ONO4059-Analog(BTK inhibitor)
- Tirabrutinib free base
- ONO-4059(Tirabrutinib)
- 8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-
- Tirabrutinib
- TIRABRUTINIB;GS-4059
- ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; TIRABRUTINIB
- 6-amino-9-[(3R)-1-(but-2-ynoyl)pyrrolidin-3-yl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
- ONO-4059;ONO 4059;ONO4059
- Tirabrutinib (ONO-4059)
- 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
- ONO-BKT
- ONO-4059(GS-4059,Tirabrutinib) free base
- ONO BTK
- Btk Kinase inhibitor