ChemicalBook >> CAS DataBase List >>Btk Kinase inhibitor
Btk Kinase inhibitor
- CAS No.
- 1351636-18-4
- Chemical Name:
- Btk Kinase inhibitor
- Synonyms
- ONO-BKT;ONO BTK;Tirabrutinib;TIRABRUTINIB;GS-4059;Btk Kinase inhibitor;ONO-4059(Tirabrutinib);Tirabrutinib free base;Isoleucine Impurity 18;Tirabrutinib (ONO-4059);ONO-4059;ONO 4059;ONO4059
- CBNumber:
- CB02716154
- Molecular Formula:
- C25H22N6O3
- Molecular Weight:
- 454.48
- MDL Number:
- MFCD28386296
- MOL File:
- 1351636-18-4.mol
Last updated:2024-04-23 09:31:34
| Boiling point | 672.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.412±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:65.0(Max Conc. mg/mL);143.02(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.66(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);66.01(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);2.2(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.16±0.20(Predicted) |
| FDA UNII | LXG44NDL2T |
| NCI Drug Dictionary | tirabrutinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Btk Kinase inhibitor price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5676 | Tirabrutinib 99.31% | 1351636-18-4 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-5676 | Tirabrutinib 99.31% | 1351636-18-4 | 10mg | $90 | 2021-12-16 | Buy |
| Activate Scientific | AS117581 | ONO-4059 98+% | 1351636-18-4 | 1mg | $94 | 2021-12-16 | Buy |
| ChemScene | CS-5676 | Tirabrutinib 99.31% | 1351636-18-4 | 25mg | $150 | 2021-12-16 | Buy |
| Activate Scientific | AS117581 | ONO-4059 98+% | 1351636-18-4 | 5mg | $180 | 2021-12-16 | Buy |
Btk Kinase inhibitor Chemical Properties,Uses,Production
Description
Btk Kinase inhibitor is highly potent and selective orally administered, small molecule, and also named tirabrutinib, Brutons tyrosine kinase (BTK) inhibitor being developed by Ono pharmaceutical and its licensee Gilead Sciences for the treatment of autoimmune disorders and haematological malignancies.
Mechanism of action
The selective inhibition of cell growth by Btk Kinase inhibitor was due to blocking of BTK-mediated signaling through AKT and cellular protein kinase D. It can inhibit autophosphorylation of the BTK at the Tyr223 position through the ERK, AKT and PKD signaling pathways.
Side effects
Adverse effects of the Btk Kinase inhibitor that occurred in some patients were rash, vomiting, neutropenia, arthralgia, and malaise, and drug-related Grade 3–4 Adverse effects were neutropenia, leukopenia, anemia, hypophosphatemia, PT-INR increased, pneumonitis, and acute myeloid leukemia. in prior Japanese studies, rash, hematologic adverse effects, erythema multiforme, and constipation were frequent adverse effects in a Phase I/II study of some patients with PCNSL, and rash, hematologic adverse effects, and stomatitis were the most common adverse effects in a Phase II study of some patients with WM.
Synthesis of Btk Kinase inhibitor from 1-Pyrrolidinecarboxylic acid, 3-[[6-[bis(phenylmethyl)amino]-5-nitro-4-pyrimidinyl]amino]-, 1,1-dimethylethyl ester, (3R)-
Btk Kinase inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 72)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 981 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
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View Lastest Price from Btk Kinase inhibitor manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-07-21 | ONO-4059
1351636-18-4
|
US $3.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | ONO-4059
1351636-18-4
|
US $3.00 / KG | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2021-11-15 | Tirabrutinib
1351636-18-4
|
US $1.20 / g | 1KG | 99% | 500ton/Month | Qiuxian Baitai New Material Co., LTD |
-
- ONO-4059
1351636-18-4
- US $3.00 / KG
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- ONO-4059
1351636-18-4
- US $3.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Tirabrutinib
1351636-18-4
- US $1.20 / g
- 99%
- Qiuxian Baitai New Material Co., LTD
1351636-18-4(Btk Kinase inhibitor)Related Search:
Btk Kinase inhibitor
ONO BTK
ONO-4059(GS-4059,Tirabrutinib) free base
ONO-BKT
6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
Tirabrutinib (ONO-4059)
ONO-4059;ONO 4059;ONO4059
6-amino-9-[(3R)-1-(but-2-ynoyl)pyrrolidin-3-yl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
ONO-4059; ONO4059; ONO 4059; ONO-4059; GS 4059; GS-4059; GS4059; ONO-WG-307; TIRABRUTINIB
TIRABRUTINIB;GS-4059
Tirabrutinib
8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-
ONO-4059(Tirabrutinib)
Tirabrutinib free base
ONO4059-Analog(BTK inhibitor)
Isoleucine Impurity 18
1351636-18-4