网站主页 >> CAS数据库列表 >> 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
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- CAS号:
- 278779-30-9
- 英文名:
- GW 4064
- 英文别名:
- CS-278;GW 4064;GW4064;GW 4064;3-(2,6-Dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole;3-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy]styryl]benzoic Acid;3-(2-Chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid;3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-ylMethoxy]phenyl]vinyl]benzoic;GW-4064,3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-ylMethoxy]phenyl]vinyl]benzoi;3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]Methoxy]phenyl]vinyl]benzoic acid;3-[2-[2-Chloro-4-[[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic Acid
- 中文名:
- 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
- 中文别名:
- GW4067中间体;GW4064,法尼醇X受体(FXR)激动剂;3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑;3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑;3-(2-氯-4-((3-(2,6-二氯苯基)-5-异丙基异恶唑-4-基)甲氧基)苯乙烯基)苯甲酸;3-[2-氯-4-[[3-(2,6-二氯苯基)-5-异丙基-4-异噁唑基]甲氧基]苯乙烯基]苯甲酸
- CBNumber:
- CB8799852
- 分子式:
- C28H22Cl3NO4
- 分子量:
- 542.84
- MOL File:
- 278779-30-9.mol
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3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑化学性质
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熔点:
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>175°C (dec.)
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沸点:
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702.1±60.0 °C(Predicted)
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密度:
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1.367±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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4.13±0.10(Predicted)
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形态:
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powder
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颜色:
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white
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3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑性质、用途与生产工艺
GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。浓度达到1 μM时，对其他核受体没有活性。GW4064在MCF-7细胞中可刺激自噬。
| Target | Value |
FXR
(CV1)
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65 nM(EC50)
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GW 4064是一种完全激动剂，在转染有鼠源和人源FXR表达载体以及确定的报告基因的CV-1细胞中， EC50分别为80和90。GW 4064直到1 μM浓度对其它核受体也没有活性，包括维甲酸受体。因此, GW 4064是一种强有效和选择性的非类固醇FXR激动剂。
大鼠体内药代动力学实验显示GW 4064口服生物利用度为10%，t
1/2
= 3.5小时。 Fisher大鼠按剂量填喂给药。7天之后, GW 4064处理的大鼠血清甘油三酯下降并具有剂量依赖特性，ED50 = 20 mg/kg。
用途
一种有效的FXR激动剂，EC50:65nM。
GW-4064 is a selective agonist of FXR(EC50=15 nM). It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM. GW-4064 upregulates adipokine expression in preadipocytes and HepG2 cells. GW4064 could reduce induction of proinflammatory cytokines by LPS in vitro.
3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-50108 | 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
GW 4064 | 278779-30-9 | 5mg | 515元 |
| 2024/04/30 | S2782 | 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
GW4064 | 278779-30-9 | 5mg | 571.57元 |
3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
生产厂家
278779-30-9, 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑 相关搜索:
- API
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- 药靶配体
- 合成有机化合物配体
- 其他生化试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 信号转导通路激酶抑制剂
- C28H22Cl3NO4
- 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
- GW4067中间体
- GW4064,法尼醇X受体(FXR)激动剂
- 3-(2-氯-4-((3-(2,6-二氯苯基)-5-异丙基异恶唑-4-基)甲氧基)苯乙烯基)苯甲酸
- 3-[2-氯-4-[[3-(2,6-二氯苯基)-5-异丙基-4-异噁唑基]甲氧基]苯乙烯基]苯甲酸
- 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
- 278779-30-9
- 3-(2-Chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid
- 3-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy]styryl]benzoic Acid
- GW4064;GW 4064
- CS-278
- GW 4064,3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoicacid
- 3-(2,6-Dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole GW 4064
- 3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-ylMethoxy]phenyl]vinyl]benzoic
- GW-4064,3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-ylMethoxy]phenyl]vinyl]benzoi
- Benzoic acid, 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-Methylethyl)-4-isoxazolyl]Methoxy]phenyl]ethenyl]-
- 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]Methoxy]phenyl]vinyl]benzoic acid
- 3-(2,6-Dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole
- 3-[2-[2-Chloro-4-[[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic Acid
- Benzoic acid, 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-GW 4064
- GW 4064