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4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline structure

CAS No.: 75483-04-4

Chemical Name:: 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

Synonyms: AI-1;AI-1 >=98% (HPLC);Nrf2 Activator II, AI-1;AI-1 (Nrf2 acticatior AI-1);Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem;4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline;Ethyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate;4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-1-methyl-2-oxo-, ethyl ester

CBNumber:: CB42696531

Molecular Formula:: C13H12ClNO3

Molecular Weight:: 265.69

MDL Number:: MFCD00634787

MOL File:: 75483-04-4.mol

Last updated:2023-07-09 08:28:05

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4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Properties

Melting point	90-92 °C
Boiling point	358.7±42.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥15mg/mL
form	powder
pka	-2.22±0.60(Predicted)
color	white to tan
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
HS Code	2933499090

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	492041	Nrf2 Activator II, AI-1	75483-04-4	25mg	$208	2024-03-01	Buy
Sigma-Aldrich	SML0009	AI-1 ≥98% (HPLC)	75483-04-4	5mg	$130	2022-05-15	Buy
American Custom Chemicals Corporation	HCH0007319	ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%	75483-04-4	1G	$1004.85	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0007319	ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%	75483-04-4	5G	$1547.7	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0007319	ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%	75483-04-4	10G	$2367.75	2021-12-16	Buy

Product number	Packaging	Price	Buy
492041	25mg	$208	Buy
SML0009	5mg	$130	Buy
HCH0007319	1G	$1004.85	Buy
HCH0007319	5G	$1547.7	Buy
HCH0007319	10G	$2367.75	Buy

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Chemical Properties,Uses,Production

Description

AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1?Cell permeable.

Uses

AI-1 is an antioxidant response element (ARE) that activates Nrf2 by covalently modifying Keap1. AI-1 is a useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

References

1) Hur?et al. (2010),?A small-molecule inducer of the antioxidant response element; Chem. Biol.,?17?537

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline synthesis

Synthesis of 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline from 1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Abmole Bioscience Inc.	021-50967598 02150967598	sales@abmole.cn	China	4495	58
Shanghai Haohong Scientific Co., Ltd.	400-400-8210725	malulu@leyan.com	China	40041	58
Nanjing Shizhou Biology Technology Co.,Ltd	--	purchase@synzest.com	China	6857	58

Supplier	Advantage
Energy Chemical	58
Abmole Bioscience Inc.	58
Shanghai Haohong Scientific Co., Ltd.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

75483-04-4(4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline)Related Search:

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4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Ethyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester AI-1 Nrf2 Activator II, AI-1 AI-1 (Nrf2 acticatior AI-1) Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem AI-1 >=98% (HPLC) 3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-1-methyl-2-oxo-, ethyl ester 75483-04-4