(-)-Indolmycin
- CAS No.
- 21200-24-8
- Chemical Name:
- (-)-Indolmycin
- Synonyms
- Pa-155-A;indolomycin;(-)-INDOLMYCIN;(S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone;[5S,(-)]-5-[(R)-1-(1H-Indol-3-yl)ethyl]-2-methylamino-2-oxazolin-4-one;4(5H)-Oxazolone, 5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-, (5S)-
- CBNumber:
- CB62347060
- Molecular Formula:
- C14H15N3O2
- Molecular Weight:
- 257.29
- MDL Number:
- MFCD01747966
- MOL File:
- 21200-24-8.mol
- MSDS File:
- SDS
| Melting point | 209-210° |
|---|---|
| alpha | D25 -214° (c = 2 in methanol) |
| Boiling point | 420.8±37.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, protect from light |
| solubility | Soluble in ethanol;methanol;DMSO;dimethyl formamide |
| form | powder |
| pka | 16.65±0.30(Predicted) |
| color | white |
| FDA UNII | ZMC93U2C8P |
(-)-Indolmycin price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15385 | Indolmycin ≥99% | 21200-24-8 | 1mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 15385 | Indolmycin ≥99% | 21200-24-8 | 5mg | $1452 | 2024-03-01 | Buy |
| TRC | I708160 | Indolmycin | 21200-24-8 | 1mg | $185 | 2021-12-16 | Buy |
| ApexBio Technology | C5289 | Indolmycin | 21200-24-8 | 5mg | $1659 | 2021-12-16 | Buy |
| AK Scientific | 0341EM | Indolmycin | 21200-24-8 | 5mg | $1715 | 2021-12-16 | Buy |
(-)-Indolmycin Chemical Properties,Uses,Production
Uses
Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.
Uses
Indolmycin is an antibiotic that inhibits bacterial tryptophanyl-tRNA synthetase.
Definition
ChEBI: A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted at the 2 and 5-pro-S positions by methylamino and [(1R)-1-(1H-indol-3-yl)ethyl] gro ps, respectively.
Biological Activity
indolmycin is an antibiotic.tryptophanyl-trna synthetase (trprs) catalyzes activation of tryptophan through atp and transfer to trnatrp , leading to translation of the genetic code for tryptophan.
in vitro
indolmycin was found to ba a bacteriostatic that showed good activity against methicillin-resistant s. aureus, methicillin-susceptible staphylococcus aureus, and vancomycin-intermediate s. aureus, including strains resistant to mupirocin or fusidic acid. spontaneous indolmycin-resistant mutants was observed at a lower frequency than those selected by mupirocin or fusidic acid and exhibited no cross-resistance with the comparative drugs. high-level resistance of indolmycin at its mic of 128 mg/l that was associated with an h43n mutation in tryptophanyl-trna synthetase, the target enzyme of indolmycin, led to loss of bacterial fitness. however, the locus responsible for low-level indolmycin resistance (indolmycin mics 8-32 mg/l) was not identified [1].
in vivo
animal study found that indolmycin could completely clear h. pylori in experimentally infected mongolian gerbils at a dose of 10 mg/kg. therefore, indolmycin could be regarded as a candidate for the treatment of h. pylori infection [2].
IC 50
30 μm for prokaryotic tryptophanyl-trna synthetase
References
[1] hurdle jg, o'neill aj, chopra i. anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. j antimicrob chemother. 2004 aug;54(2):549-52. epub 2004 jul 8.
[2] vecchione jj, sello jk. a novel tryptophanyl-trna synthetase gene confers high-level resistance to indolmycin. antimicrob agents chemother 2009; 53: 3972-3980.
(-)-Indolmycin Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-Indolmycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
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| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |