パノビノスタット
パノビノスタット 物理性質
- 融点 :
- 114-117?C
- 比重(密度) :
- 1.241±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C Freezer, Under Inert Atmosphere
- 溶解性:
- DMSO (最大 100mg/ml) またはエタノール (加熱により最大 5mg/ml) に可溶。
- 外見 :
- 個体
- 酸解離定数(Pka):
- 8.71±0.23(Predicted)
- 色:
- オフホワイト
- 安定性：:
- -20°C の DMSO またはエタノール溶液で最大 1 か月間保存できます。
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-2967 |
パノビノスタット
Panobinostat |
404950-80-7 |
250mg |
￥108000 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-2967 |
パノビノスタット
Panobinostat |
404950-80-7 |
1g |
￥273600 |
2018-12-26 |
購入 |
パノビノスタット 化学特性,用途語,生産方法
効能
抗悪性腫瘍薬, ヒストン脱アセチル化酵素阻害薬
説明
Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with K
i values ranging from 0.6 to 31 nM for HDAC1-
11. Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells. It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.
化学的特性
Yellow Solid
使用
The novel labelled histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
定義
ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its la
tate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
パノビノスタット 上流と下流の製品情報
原材料
準備製品
パノビノスタット 生産企業
Global( 245)Suppliers
404950-80-7(パノビノスタット)キーワード:
- 404950-80-7
- (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE
- N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
- LBH-589/Panobinostat
- LBH-589
- PANOBINOSTAT
- 2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)-, (2E)-
- NVP-LBH589
- Panobinostat (LBH589)
- (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
- N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide Panobinostat (LBH589)
- Panobinostat
N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
- panobinostat (HDAC inhibitor)
- Panobinostat (LBH589, NVP-LBH589)
- Palcociclib
- Panobinostat, >=98%
- LBH-589; LBH589; NVP-LBH589
- CS-422
- LBH 589 - NVP-LBH 589 | Panobinostat
- 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenohydroxamic acid
- (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
- Panobinostat USP/EP/BP
- 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E...
- Panobinostat D7
- 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenohydroxamic acid N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
- Palmer than he
- LBH 589,Human immunodeficiency virus,Histone deacetylases,HIV,HDAC,LBH-589,Autophagy,inhibit,Panobinostat,Inhibitor,Apoptosis
- panobinosta
- 2-Acrylamide
- Papistatin impurity
- パノビノスタット
- (E)-N-ヒドロキシ-3-[4-[[[2-(2-メチル-1H-インドール-3-イル)エチル]アミノ]メチル]フェニル]アクリルアミド
- (E)-N-ヒドロキシ-3-[4-[[[2-(2-メチル-1H-インドール-3-イル)エチル]アミノ]メチル]フェニル]プロペンアミド
- (2E)-N-ヒドロキシ-3-[4-({[2-(2-メチル-1H-インドール-3-イル)エチル]アミノ}メチル)フェニル]プロパ-2-エンアミド