시클로피록스올아민
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시클로피록스올아민 속성
- 녹는점
- 144 C
- 밀도
- 0.41g/cm3 at 25℃
- 증기압
- 0-0Pa at 20-50℃
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 용해도
- 물에 조금 녹고, 에탄올(96%)과 염화메틸렌에 매우 잘 녹고, 에틸 아세테이트에 약간 녹고, 시클로헥산에는 거의 녹지 않습니다.
- 색상
- 흰색에서 황백색까지
- LogP
- 0.52
- CAS 데이터베이스
- 41621-49-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-42/43-20/22 | ||
| 안전지침서 | 26-36-22 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | UU7785500 | ||
| HS 번호 | 2933790002 | ||
| 독성 | LD50 in mice, rats (mg/kg): 2898, 3290 orally (Alpermann, Schutz) |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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시클로피록스올아민 C화학적 특성, 용도, 생산
화학적 성질
White or pale yellow, crystalline powder.용도
Ciclopirox ethanolamine is a broad spectrum antimycotic agent with some antibacterial activity.정의
ChEBI: The ethanolamine salt of ciclopirox. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin an nail infections.Indications
Ciclopirox olamine (Loprox, Penlac) is a synthetic, broad-spectrum hydroxypyridone antifungal agent. It is chemically unrelated to the imidazoles or any other antifungal agent currently available in the United States. It appears to act through intracellular depletion of substrates and/or ions principally by inhibition of transmembrane transport of these substances. It is active against dermatophytes, yeast, and Pityrosporum orbiculare. It also demonstrates activity against Trichomonas vaginalis, some mycoplasma, and some gram-positive and gram-negative bacteria.Clinical Use
6-Cyclohexyl-1-hydroxyl-4-methyl-2(1H)-pyridinoneethanolamine salt (Loprox) is a broad-spectrum antifungalagent intended only for topical use. It is active against dermatophytesas well as pathogenic yeasts (C. albicans) thatare causative agents for superficial fungal infections.Ciclopirox is considered an agent of choice in the treatmentof cutaneous candidiasis, tinea corporis, tinea cruris,tinea pedis, and tinea versicolor. It is a second-line agent forthe treatment of onychomycosis (ringworm of the nails).Loprox is formulated as a cream and a lotion, each containing1% of the water-soluble ethanolamine salt. Ciclopirox isbelieved to act on cell membranes of susceptible fungi atlow concentrations to block the transport of amino acids intothe cells. At higher concentrations, membrane integrity islost, and cellular constituents leak out.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic fumes ofNOx.시클로피록스올아민 준비 용품 및 원자재
원자재
준비 용품
시클로피록스올아민 공급 업체
글로벌( 403)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| APOLLO HEALTHCARE RESOURCES | +6596580999 |
sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
| Hebei Duling International Trade Co. LTD | +8617333973358 |
sales01@hbduling.cn | China | 15620 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 |
sales01@airuikechemical.com | China | 994 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15954 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9340 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |