말론산 디메틸
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말론산 디메틸 속성
- 녹는점
- -62 °C (lit.)
- 끓는 점
- 180-181 °C (lit.)
- 밀도
- 1.156 g/mL at 25 °C (lit.)
- 증기 밀도
- >1 (vs air)
- 증기압
- 0.15 hPa (20 °C)
- 굴절률
- n
20/D 1.413(lit.)
- 인화점
- 194 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 알코올: 혼합 가능
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- 11.80±0.46(Predicted)
- 색상
- 무색의
- 냄새
- 과일 같은
- 폭발한계
- 1.3-17.4%(V)
- 수용성
- 무시할 만한
- Merck
- 14,6096
- BRN
- 774261
- Dielectric constant
- 10.4（20℃）
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다. 가연성.
- InChIKey
- BEPAFCGSDWSTEL-UHFFFAOYSA-N
- LogP
- -0.05 at 20-25℃ and pH6.4
- CAS 데이터베이스
- 108-59-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 1 | ||
| RTECS 번호 | OO0950000 | ||
| 자연 발화 온도 | 440 °C | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| HS 번호 | 29171910 | ||
| 독성 | LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg | ||
| 기존화학 물질 | KE-24322 |
말론산 디메틸 C화학적 특성, 용도, 생산
안전성
밀봉하여 건조한 냉암소에 저장한다.안전성
제4류 인화성액체개요
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.화학적 성질
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.용도
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.주요 응용
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
생산 방법
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.일반 설명
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.말론산 디메틸 준비 용품 및 원자재
원자재
준비 용품
Dimethyl ethylmalonate
Methyl 3-cyclopentenecarboxylate
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
2-Methylpyrimidine
메톡시말론산디메틸에스테르
Primisulfuron-methyl
5-플루오로-2-옥신돌
Pipemidic acid
5-(2-ETHYLTHIO PROPYL)-1,3-CYCLOHEXANEDIONE
3-(4-플루오로페닐)프로피온산
8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
5-(TETRAHYDRO-2H-THIOPYRAN-3-YL)-1,3-CYCLOHEXANEDIONE
1-AMINO-CYCLOPROPANEMETHANOL
1,1-Cyclopropanedicarboxylic acid dimethyl ester
Chlorimuron-ethyl
ADS
DIMETHYL BROMOMALONATE
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
MALONIC ACID DI-N-BUTYL ESTER
3-CARBETHOXY-4-HYDROXYCOUMARIN
6-CHLORO-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID
TERT-BUTYL METHYL MALONATE
세톡시딤
Dimethyl chloromalonate
6-Chlorooxindole
5-MESITYL-1,3-CYCLOHEXANEDIONE
말론산 디메틸 공급 업체
글로벌( 678)공급 업체
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