눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P321
(…) 처치를 하시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P333+P313
피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P363
다시 사용전 오염된 의류는 세척하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
Liranaftate C화학적 특성, 용도, 생산
개요
Liranaftate was launched in Japan as a new topical antifungal for the treatment of
dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can
be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl
chloride. It is a potent and specific inhibitor of squalene epoxidase
and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable
effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels.
Liranaftate was found to be significantly more active than the other thiocarbamate
tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and
against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was
inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
