6-Methylisoquinoline
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6-Methylisoquinoline 속성
- 녹는점
- 85.5°C
- 끓는 점
- 246.29°C (estimate)
- 밀도
- 1.0584 (estimate)
- 굴절률
- 1.6103 (estimate)
- 산도 계수 (pKa)
- 5.85±0.10(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 베이지색
- CAS 데이터베이스
- 42398-73-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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유해·위험 문구: |
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예방조치문구: |
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6-Methylisoquinoline C화학적 특성, 용도, 생산
화학적 성질
Light beige powder용도
6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.제조 방법
A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).6-Methylisoquinoline 준비 용품 및 원자재
원자재
P-톨루엔설폰 산
에틸알코올
아미노아세트알데하이드디메틸아세탈
4-메틸벤즈알데히드
톨루엔
나트륨 붕소수화물
트리에틸아민
클로로포름산에틸
염화알루미늄
파라-톨루엔설폰일 염화물
테트라하이드로푸란
트리메틸포스파이트
타르타르산 나트륨 칼륨
염산
중탄산나트륨(중조)
디클로로메탄
염화티탄(Ⅳ)
피리딘
준비 용품
6-Methylisoquinoline 공급 업체
글로벌( 95)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 |
abby@arkpharm.com | CHINA | 3279 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10828 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27644 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15396 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
6-Methylisoquinoline 관련 검색:
나트륨 CMC 2,6-자일렌올 2,6-루티딘 이소퀴놀린 N,N-다이메틸폼아마이드 카르복심틸셀룰로오스
1,2,3,4-TETRAHYDROISOQUINOLINE
6-methylisoquinolin-3-amine
methylisoquinolin
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
3-Methylisoquinoline
7-Methyl isoquinoline
Atracurium besylate
Cisatracurium besylate
6-isoquinolinecarboxylic acid
6-Isoquinolinecarboxaldehyde (9CI)
6-(bromomethyl)isoquinoline
4-CYANO-3-METHYLISOQUINOLINE