4-아미노안티피린
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4-아미노안티피린 속성
- 녹는점
- 105-110 °C(lit.)
- 끓는 점
- 340 C
- 밀도
- 0.8
- 굴절률
- 1.4930 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- H2O: 0.1 g/mL, 투명
- 산도 계수 (pKa)
- pK1: 4.94(+1) (25°C)
- 물리적 상태
- 분말 또는 결정
- 색상
- 노란색에서 황갈색
- 수소이온지수(pH)
- 7.1 (100g/l, H2O, 20℃)(slurry)
- 냄새
- 냄새 없는
- 수용성
- ca. 500g/L(20℃)
- Merck
- 14,591
- BRN
- 181635
- 안정성
- 안정적인. 빛에 민감할 수 있습니다.
- LogP
- -0.257 (est)
- CAS 데이터베이스
- 83-07-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
안전지침서 | 26-36-36/37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | CD2480000 | ||
F 고인화성물질 | 8-9-23 | ||
위험 참고 사항 | Harmful | ||
TSCA | Yes | ||
HS 번호 | 29331190 | ||
독성 | LD50 orally in Rabbit: 1700 mg/kg | ||
기존화학 물질 | KE-01297 |
4-아미노안티피린 C화학적 특성, 용도, 생산
화학적 성질
Amber crystalline powder주요 응용
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.
용도
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
제조 방법
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.정의
ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.일반 설명
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.Purification Methods
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]4-아미노안티피린 준비 용품 및 원자재
원자재
이아황산 암모늄, 고체
Iodine solution
아질산 나트륨
안티피린
Starch paper
황산
2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one
준비 용품
Aminopyrine
N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide
1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one
암모늄 알긴염
Ramifenazone
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide
2-CYANO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE
3-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)PROPANAMIDE
AMINOPROPYLON
4-아미노안티피린 공급 업체
글로벌( 404)공급 업체
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LEAP CHEM CO., LTD. | +86-852-30606658 |
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Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
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Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
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career henan chemical co | +86-0371-86658258 |
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Hubei xin bonus chemical co. LTD | 86-13657291602 |
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Standardpharm Co. Ltd. | 86-714-3992388 |
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