메틸 P-톨루엔 설포네이트
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메틸 P-톨루엔 설포네이트 속성
- 녹는점
- 25-28 °C(lit.)
- 끓는 점
- 144-145 °C5 mm Hg(lit.)
- 밀도
- 1.234 g/mL at 25 °C(lit.)
- 증기 밀도
- 6.45 (vs air)
- 증기압
- 1 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.5172(lit.)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 액체 또는 저융점 고체
- 색상
- 흰색에서 노란색으로
- 수용성
- 불용성
- 감도
- Moisture Sensitive
- BRN
- 609209
- LogP
- 1.88 at 25℃
- CAS 데이터베이스
- 80-48-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-34-43-40-36/37/38 | ||
| 안전지침서 | 26-36/37/39-45-24 | ||
| 유엔번호(UN No.) | UN 3261 8/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | XT7000000 | ||
| F 고인화성물질 | 21 | ||
| 자연 발화 온도 | 896 °F | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29051900 | ||
| 유해 물질 데이터 | 80-48-8(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: 341 mg/kg | ||
| 기존화학 물질 | KE-23478 |
메틸 P-톨루엔 설포네이트 C화학적 특성, 용도, 생산
화학적 성질
white to slightly yellow low melting solid. Soluble in alcohol, ether, benzene, insoluble in water. Hygroscopic.용도
Methyl p-Toluenesulfonate can be used in the manufacture of dyes and organic synthesis, and also is the raw materials of methylation.제조 방법
Methyl p-toluenesulfonate was synthesized by the reaction of p-toluenesulfonyl chloride with methanol. Mix p-toluenesulfonyl chloride and methanol, slowly add 25% sodium hydroxide solution, control the temperature below 25 °C, stop adding alkali when the pH is 9, continue stirring for 2 hours, and leave overnight. The lower layer of reactant was taken, the upper layer was extracted with benzene, the extract was recovered with benzene and then combined with the lower layer, washed with water and 5% potassium carbonate solution in turn, dried and distilled under reduced pressure to obtain the finished product of methyl p-toluenesulfonate.일반 설명
Methyl p-toluenesulfonate is sulfonate ester present as potentially genotoxic impurity in drug substances. Kinetics of reactions of methyl p-toluenesulfonate with N,N-dimethylaniline has been investigated. It participates in selective 1-substitution reaction of tetrazole.위험도
Toxic by ingestion and inhalation, strongirritant to skin and eyes.Safety Profile
Poison by ingestion and subcutaneous routes. An eye and severe skin irritant. A vesicant and skin sensitizer. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of SOx.Purification Methods
The ester is purified by distillation in vacuo and could be crystallised from pet ether or Et2O/pet ether at low temperature. It is a powerful methylating agent, is TOXIC andis a skin irritant, so it is better to purify it by repeated distillation. [IR: Schreiber Anal Chem 21 1168 1949, Buehler et al. J Org Chem 2 167 1937, Roos et al. Org Synth Coll Vol I 145 1948, Beilstein 11 IV 247.]메틸 P-톨루엔 설포네이트 준비 용품 및 원자재
원자재
파라-톨루엔설폰일 염화물
4-methylbenzenediazonium tetrafluoroborate
Tetrabutylammonium 4-toluenesulfonate
[Hydroxy(tosyloxy)iodo]benzene
4-Toluenesulfonyl bromide
2,2,2-TRIFLUOROETHYL METHYL ETHER
디메틸아연
트라이메틸 오쏘아세트산
준비 용품
트리메틸-1,3,3,-2-메틸렌인돌린
5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE
2,5-diphenylthiazole
3,5-Bis(2-cyanoprop-2-yl)toluene
1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene
노닌(2-)
플루오린화 메틸(플루오르화 메틸)
METHYL 3,5-DIMETHYLBENZOATE
2-CHLORO-1-METHYLPYRIDINIUM P-TOLUENESULFONATE
에틸 메틸 에테르
3,6-diamino-2,7,10-trimethylacridinium chloride
Basic Orange 5
메틸 P-톨루엔 설포네이트 공급 업체
글로벌( 514)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 |
sales@anikare.com | China | 8393 | 58 |
| Shouguang Nuomeng Chemical Co Ltd. | 536-5119508 18363669993; |
export@nuomengchem.com | China | 44 | 58 |
| Junwee Chemical co., Ltd. | +86-571-85808636 +86-13958122542 |
sales@junweechem.com | China | 821 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12471 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18229 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 |
wrjmoon2000@163.com | China | 357 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15957 | 58 |