Cefoxitin
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Cefoxitin 속성
- 녹는점
- 149-150℃
- 끓는 점
- 843℃
- 밀도
- 1.4441 (rough estimate)
- 굴절률
- 1.6390 (estimate)
- RTECS 번호
- XI0386500
- 인화점
- >110°(230°F)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.2(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 예상되는 물의 용해도는 0.2mg/ml 미만입니다.
- CAS 데이터베이스
- 35607-66-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) | 3077 | ||
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위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 30032013 |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Cefoxitin C화학적 특성, 용도, 생산
개요
Cefoxitin contains the same C-7 side chain as cephalothin and the same C-3 side chain as cefuroxime. The most novel chemical feature of cefoxitin is the possession of an α-oriented methoxyl group in place of the normal H-atom at C-7. This increased steric bulk conveys very significant stability against β-lactamases. The inspiration for these functional groups was provided by the discovery of the naturally occurring antibiotic cephamycin C derived from fermentation of Streptomyces lactamdurans. Cephamycin C itself has not seen clinical use but, rather, has provided the structural clue that led to useful agents such as cefoxitin. Agents that contain this 7α methoxy group are commonly referred to as cephamycins. Ingenious chemical transformations now enable synthetic introduction of such a methoxy group into cephalosporins lacking this feature.용도
Cefoxitin?is a semisynthetic, broad-spectrum second-generation cephalosporin with antibacterial activity. The activity of cefoxitin results in the weakening of the bacterial cell wall and causes cell lysis. Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes.Antimicrobial activity
Most Gram-positive bacilli are susceptible, but L. monocytogenes is resistant. It is resistant to many Gramnegative β-lactamases and is active against organisms elaborating them, including some Citrobacter, Providencia, Serratia and Acinetobacter spp. Enterobacter spp. are resistant. It is moderately active against Bacteroides spp., but considerable strain variation in susceptibility occurs.원료
Resistant strains of Bacteroides, some of which produce β-lactamases that hydrolyze cefoxitin, have been described. Resistance may be transferable to other Bacteroides spp. It is a potent inducer of chromosomal cephalosporinases of certain Gram-negative bacilli and can antagonize the effect of cefotaxime and other β-lactam agents.Clinical Use
As for other group 3 cephalosporins, with particular emphasis on mixed infections including anaerobes, notably abdominal and pelvic sepsis. In considering its use, its low activity against aerobic Gram-positive cocci should be noted.부작용
Reactions are those common to cephalosporins. Pain on intramuscular, and thrombophlebitis on intravenous, injection occur. Substantial changes can occur in the fecal flora, with virtual eradication of susceptible enterobacteria and non- fragilis Bacteroides, and appearance of, or increase in, yeasts, enterococci and other resistant bacteria including C. difficile. Development of meningitis due to H. influenzae and Str. pneumoniae in patients treated for other infections has been observed.Cefoxitin 준비 용품 및 원자재
원자재
디메틸설페이트
수소화나트륨
트리플루오로아세트 산
(6R-cis)-3-(acetoxymethyl)-7-methoxy-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cephalothin
데아세틸세팔로스포린C
클로로설포닐이소시아네이트
2-티오펜아세틸 염화물
7-아미노세팔로스포란산
준비 용품
Cefoxitin 공급 업체
글로벌( 235)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 13172 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
Hebei Henghe Import and Export Trading Co. LTD | +8618032935937 18032916000 |
demi@hbtycoon.com | CHINA | 449 | 58 |