| Company Name: |
BOC Sciences
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16314854226 |
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info@bocsci.com |
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Product Name:Thioetheramide-PC
CAS:116457-99-9
Purity:95% Package:1G;10G;100G Remarks:Thioetheramide-PC is a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). It binds to the catalytic site and the activator site of sPLA2. At low concentrations, thioetheramide-PC
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| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:Thioetheramide phosphorylcholine
CAS:116457-99-9
Purity:98% (TLC) Package:5mg;10mg;25mg
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Thioetheramide-PC
CAS:116457-99-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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Product Name:1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS:116457-99-9
Purity:98% Package:5mg (solution); 10mg (solution); 25mg (solution) Remarks:Medbio
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| | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Basic information |
| Product Name: | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE | | Synonyms: | 1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;THIOETHERAMIDE PC;Thioetheramide phosphorylcholine;WLWWVTPUDQTUJU-KDXMTYKHSA-N;3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)- | | CAS: | 116457-99-9 | | MF: | C45H93N2O4PS | | MW: | 789.27 | | EINECS: | | | Product Categories: | | | Mol File: | 116457-99-9.mol |  |
| | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO;Soluble in dimethyl formamide | | form | White solid. |
| | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis |
| Description | Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it. | | references | [1] yu l, deems r a, hajdu j, et al. the interaction of phospholipase a2 with phospholipid analogues and inhibitors[j]. journal of biological chemistry, 1990, 265(5): 2657-2664.
[2] balsinde j, balboa m a, insel p a, et al. regulation and inhibition of phospholipase a2[j]. annual review of pharmacology and toxicology, 1999, 39(1): 175-189.
[3] mallat z, lambeau g, tedgui a. lipoprotein-associated and secreted phospholipases a2 in cardiovascular disease[j]. circulation, 2010, 122(21): 2183-2200. |
| | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials |
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