|
|
| | U-73343 Basic information |
| Product Name: | U-73343 | | Synonyms: | U-73343;1-[6-[((17Β)-3-METHOXYESTRA-1,3,5[10]-TRIEN-17-YL)AMINO]HEXYL]-2,5-PYRROLIDINEDIONE;1-[6-((17BETA-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL]-2,5-PYRROLIDINEDIONE;U-73343;1-[6-[((17β)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione;3-Methoxy-17-[6-(2,5-dioxopyrrolidin-1-yl)hexylamino]estra-1,3,5(10)-triene;U73343, U-73343, U 73343;U-73343 - CAS 142878-12-4 - Calbiochem;2,5-Pyrrolidinedione, 1-[6-[[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]- | | CAS: | 142878-12-4 | | MF: | C29H42N2O3 | | MW: | 466.66 | | EINECS: | | | Product Categories: | APIS | | Mol File: | 142878-12-4.mol |  |
| | U-73343 Chemical Properties |
| Boiling point | 641.5±55.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | +15C to +30C | | solubility | ethanol: 0.93 mg/mL | | form | powder | | pka | 10.68±0.40(Predicted) | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Dried films prepared from chloroform solution are stable for at least 1 month at -20°. It is preferable to dissolve U-73343 immediately before use if at all possible. Use caution and retest potency if attempting. |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | U-73343 Usage And Synthesis |
| Description | U-73343 (142878-12-4) is a negative control for phospholipase C inhibitor U-73122 (Cat.# 10-1061).1,2 Elicits unexpected effects on rabbit parietal cells.3?Cell permeable. | | Uses | U-73343 is an inactive structural analog of U-73122. | | General Description | A cell-permeable analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control. | | Biochem/physiol Actions | Cell permeable: yes | | storage | Store at RT | | References | 1) Bleasdale?et al. (1990),?Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther.,?255?756
2) Morley?et al. (1992),?A new, nongenomic estrogen action: the rapid release of intracellular calcium; Endocrinology,131?1305
3) Muto?et al. (1997),?The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell; J. Pharmacol. Exp. Ther.,?282?1379 |
| | U-73343 Preparation Products And Raw materials |
|