| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:BW-B 70C;N-[3-[3-(-Fluorophenoxy)phenyl]-1-Methyl-2-propenyl]-N-hydroxyurea
CAS:134470-38-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
|
| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:BW B70C
CAS:134470-38-5
Purity:>=98% (HPLC) Package:5MG; 25MG; 100MG; 1G
|
|
| | BW B70C Basic information |
| Product Name: | BW B70C | | Synonyms: | N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;(e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure;70c;n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure;BW B70C;Urea, N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy- | | CAS: | 134470-38-5 | | MF: | C17H17FN2O3 | | MW: | 316.33 | | EINECS: | | | Product Categories: | | | Mol File: | 134470-38-5.mol |  |
| | BW B70C Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 22 mg/mL, soluble | | form | solid | | color | white |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | YT3976666 |
| | BW B70C Usage And Synthesis |
| Uses | BW B70C is a 5-LO (5-lipoxygenase) inhibitor. | | Definition | ChEBI: A hydroxamic acid that is urea in which both the hydrogens attached to one of the nitrogens are replaced by a hydroxy and a (1E)-1-[3-(4-fluorophenoxy)phenyl]but-1-en-3-yl group. A selective inhibitor of arachidonate 5-lipoxygenase, it ca
be used for the treatment of asthma. | | Biological Activity | A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability. | | references | [1]. payne an, jackson wp, salmon ja, et al. hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. agents actions suppl, 1991, 34: 189-199.
[2]. yeadon m, dougan fl, petrovic a, et al. effect of bw b70c, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. agents actions, 1993, 38(1-2): 8-18.
[3]. bureau mf, de castro cm, cortese c, et al. 5-lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. eur j pharmacol, 1997, 324(1): 89-98.
[4]. jatana m, giri s, ansari ma, et al. inhibition of nf-kappab activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. j neuroinflammation, 2006, 3: 12. |
| | BW B70C Preparation Products And Raw materials |
|