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| | PD 146176 Basic information |
| Product Name: | PD 146176 | | Synonyms: | 6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;PD146176 (NSC168807);NSC168807;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis | | CAS: | 4079-26-9 | | MF: | C15H11NS | | MW: | 237.32 | | EINECS: | | | Product Categories: | | | Mol File: | 4079-26-9.mol |  |
| | PD 146176 Chemical Properties |
| Melting point | 160 °C | | Boiling point | 485.4±24.0 °C(Predicted) | | density | 1.333±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: 16 mg/mL, soluble | | form | solid | | pka | 16.17±0.20(Predicted) | | color | cream-colored |
| | PD 146176 Usage And Synthesis |
| Description | PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP. In addition, it lacks significant non-specific antioxidant properties. | | Uses | PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue. | | Definition | ChEBI: PD-146176 is an organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. It has a role as a ferroptosis inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an antiatherogenic agent. It is an organic heterotetracyclic compound, an organosulfur heterocyclic compound and an organonitrogen heterocyclic compound. | | Biological Activity | Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo . | | Biochem/physiol Actions | PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme. | | storage | Store at +4°C |
| | PD 146176 Preparation Products And Raw materials |
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