| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:LE 300;6,7,8,9,14,15-Hexahydro-7-Methyl-5H-indolo[3,2-f][3]benzazecine
CAS:274694-98-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:LE 300
CAS:274694-98-3
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
|
| Product Name: | LE 300 | | Synonyms: | 7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE;6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE;6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine;LE 300;5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl- | | CAS: | 274694-98-3 | | MF: | C20H22N2 | | MW: | 290.4 | | EINECS: | | | Product Categories: | Dopamine receptor | | Mol File: | 274694-98-3.mol |  |
| | LE 300 Chemical Properties |
| Melting point | >91°C (dec.) | | storage temp. | Store at RT | | solubility | DMSO: 26 mg/mL | | form | solid | | color | Off-White to Pale Beige | | Stability: | Hygroscopic |
| | LE 300 Usage And Synthesis |
| Description | LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg). | | Uses | LE 300 is a potent and selective dopamine receptor antagonist. | | Definition | ChEBI: LSM-2007 is a member of indoles. | | Biological Activity | Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo . | | storage | Room temperature |
| | LE 300 Preparation Products And Raw materials |
|