ChemicalBook CAS DataBase List 2-Aminobenzotrifluoride

2-Aminobenzotrifluoride synthesis

9synthesis methods

Product Name:2-Aminobenzotrifluoride
CAS Number:88-17-5
Molecular formula:C7H6F3N
Molecular Weight:161.12

81290-20-2 Synthesis

81290-20-2
397 suppliers
$13.00/1g

62-53-3 Synthesis

62-53-3
631 suppliers
$10.00/1g

88-17-5
362 suppliers
$14.00/25g

Yield:88-17-5 89%

Reaction Conditions:

with 1-acetoxy-1,2-benziodoxol-3-one;potassium acetate in acetonitrile at 80; for 13 h;Reagent/catalyst;Solvent;Temperature;Time;

Steps:

1-23 Synthesis through the following method
General procedure: Add magnetic particles to a dry 50 mL three-neck reaction flask at room temperature, then add 20 mL of anhydrous B.The nitrile was added to the dry acetonitrile with stirring, then trifluoromethyltrimethylsilane (213 mg, 1.5 mmol) was added, then anhydrous potassium acetate (147 mg, 1.5 mmol) was added. Then, the reaction liquid was heated to 80 ° C, aniline (93 mg, 1.0 mmol) was dissolved in 5 mL of anhydrous acetonitrile, and then the aniline solution was slowly added dropwise to the above-mentioned 80 ° C reaction solution by a constant pressure dropping funnel. Approx. 1 hour. After the dropwise addition was completed, the reaction was carried out at 80 ° C for 12 hours. The reaction solution was cooled to room temperature, and the solid was filtered off, and then the reaction mixture was evaporated to dryness to afford the desired product.

References:

Zhengzhou Engineering Technology College;Li Hua;Wang Huanfeng;Jiang Qiaojuan CN108440310, 2018, A Location in patent:Page/Page column 7-11

FullText

887144-94-7 Synthesis