ChemicalBook CAS DataBase List 4-Aminotetrahydropyran

4-Aminotetrahydropyran synthesis

8synthesis methods

Product Name:4-Aminotetrahydropyran
CAS Number:38041-19-9
Molecular formula:C5H11NO
Molecular Weight:101.15

4-Aminotetrahydropyran can be synthesized from 4-cyanotetrahydropyran and sodium hydroxide solution as raw materials to synthesize 4-formamide tetrahydropyran, and then slowly add sodium hypochlorite solution to 4-formamide tetrahydropyran. Synthesized by decarboxylation.

29943-42-8 Synthesis

29943-42-8
420 suppliers
$5.00/1g

38041-19-9
316 suppliers
$6.00/1g

Yield:38041-19-9 90 %Chromat.

Reaction Conditions:

with ammonium hydroxide;nickel-aluminum alloy;water at 20; for 2 h;Sonication;Green chemistry;

Steps:

Reductive Amination of Ketones in NH₄OH; Cyclohexylamine; Typical Procedure
General procedure: Ni-Al alloy (200 mg) and cyclohexanone (35 μL, 0.34 mmol) were suspended in 28-30% NH₄OH (3 mL) and sonicated (Branson 1510MTH ultrasonic bath) for 2 h. After the completion of the reaction, the excess alloy and solid by-products were removed by filtration. The filtrate was extracted with EtOAc (2 × 2 mL). The organic extracts were combined and dried over anhyd Na₂SO₄. The solvent was removed in vacuo and the crude product was purified by flash chromatography.

References:

Schäfer, Christian;Niśanci, Bilal;Bere, Matthew P.;Daśtan, Arif;Török, Béla [Synthesis,2016,vol. 48,# 18,art. no. SS-2016-M0224-OP,p. 3127 - 3133]