ChemicalBook CAS DataBase List 4-(Trifluoromethoxy)aniline

4-(Trifluoromethoxy)aniline synthesis

10synthesis methods

Product Name:4-(Trifluoromethoxy)aniline
CAS Number:461-82-5
Molecular formula:C7H6F3NO
Molecular Weight:177.12

456-55-3
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$6.00/10g

461-82-5
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$10.00/1g

Yield:461-82-5 98.2%

Reaction Conditions:

Stage #1:1-trifluoromethoxybenzene with sodium ferrate(VI);sodium bromide in dimethyl sulfoxide at 95; for 4 h;Inert atmosphere;
Stage #2: with sodium amide in dimethyl sulfoxide at 155; under 3040.2 Torr; for 10 h;Inert atmosphere;Solvent;Temperature;Reagent/catalyst;Pressure;

Steps:

1 Example 1 The method for synthesizing trifluoromethoxyaniline comprises the following steps:
1) Add 1 mol of trifluoromethoxybenzene and anhydrous DMSO to the reaction vessel under argon and vigorous stirring. Then add sodium ferrate and sodium bromide as auxiliary reaction mixture, heat to 95 ° C for 4 h, then add sodium amide, The temperature was raised to 155 ° C, the reaction pressure was raised to 4 atm, and the reaction was continued for 10 h; The ratio of trifluoromethoxybenzene to sodium amide is 1:4.5, The ratio of the amount of the trifluoromethoxybenzene to the auxiliary reaction mixture was 1:1.4. The ratio of sodium ferrate to sodium bromide is 1:1. 2) After cooling the system, pour it into 8 volumes of water. The extract was extracted with 4 times the original reaction volume of chloroform, and the extract was washed with water and dried over anhydrous sodium sulfate. Then concentrated to give the product in a molar yield of 98.2%, HPLC purity 97.7%

References:

Shandong Nong Pharmaceutical Xue Institute;Jinan Kehai Co., Ltd.;Fu Hongxin;Yang Chaohui;Wang Ling CN109134277, 2019, A Location in patent:Paragraph 0025-0049

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713-65-5 Synthesis