BIS-(4-FLUORO-PHENYL)-PHENYL-METHANOL synthesis
- Product Name:BIS-(4-FLUORO-PHENYL)-PHENYL-METHANOL
- CAS Number:379-55-5
- Molecular formula:C19H14F2O
- Molecular Weight:296.31
Yield:-
Reaction Conditions:
with hydrogenchloride in tert-butylmethyl ether
Steps:
1 1.3a Synthesis of bis(4-fluorophenyl)phenylmethanol
1.3a Synthesis of bis(4-fluorophenyl)phenylmethanol Phenylmagnesium bromide (100 mL, 0.1 mol) was added dropwise to a stirring solution of 4,4'-difluorobenzophenone (20 g, 0.092 mol) in t-butylmethyl ether (150 mL) at rt. After the addition was complete the reaction was heated at reflux for 3 h. The solution was cooled to rt and was poured in to ice cold aqueous 1.0 M HCl (100 mL). The organics were extracted with EtOAc (2*50 mL) and dried (Na2SO4). Concentration under reduced pressure gave bis(4-fluorophenyl)phenylmethanol as a pale brown oil. After drying in vacuo for 2 h the crude material was used in the next reaction without any further purification.
References:
Icagen, Inc. US6288122, 2001, B1
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