ChemicalBook CAS DataBase List Ethylamine hydrochloride

Ethylamine hydrochloride synthesis

10synthesis methods

Product Name:Ethylamine hydrochloride
CAS Number:557-66-4
Molecular formula:C2H8ClN
Molecular Weight:81.54

Ethylamine can be synthesized by ethanol and ammonia are combined in the presence of an oxide catalyst:
CH3CH2OH + NH3 → CH3CH2NH2 + H2O
Ethylamine could then be solvent extracted or boiled out of hoffman turned to Hydrochloride with HCl and then freebased with caustic to be distilled pure.
of course an excess of caustic when freebasing would be a good idea as it would hold onto most of the water created from the basing of a hydrochloride with caustic.

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Yield:557-66-4 133 mg

Reaction Conditions:

with hydrogenchloride in water monomer at 20; for 2 h;

Steps:

General procedure: For the isolation of deoxygenated products, 1M HCl solution was added to the reaction mixture. The reaction mixture was then stirred at room temperature for two hours, precipitating a solid that was extracted and collected with dichloromethane three times. The combined aqueous layers were dried. The products were identified according to ¹H and ¹³C{¹H} NMR spectroscopy. Yields were calculated on the basis of isolated yields.

References:

Bandyopadhyay, Ayan;Bhattacharjee, Jayeeta;Kumar Singh, Saurabh;Kumari, Kusum;Moorthy, Shruti;Panda, Tarun K.;Sai Kumar, Gobbilla [Polyhedron,2022,vol. 219,art. no. 115784] Location in patent:supporting information