ChemicalBook CAS DataBase List Micafungin Side Chain Methyl Ester

Micafungin Side Chain Methyl Ester synthesis

8synthesis methods

Product Name:Micafungin Side Chain Methyl Ester
CAS Number:179162-64-2
Molecular formula:C22H23NO4
Molecular Weight:365.42

123-08-0 Synthesis

123-08-0
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 24 h / 60 - 70 °C / Inert atmosphere
2.1: triphenylphosphine / dichloromethane / 0.67 h / 0 °C / Inert atmosphere
2.2: 2.17 h / 0 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
4.1: potassium carbonate; copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 5 h / 20 °C / Inert atmosphere

References:

Rao, Pallavi;Hussain, Ismail;Rao, Venkataramanarao;Sen, Saikat;Oruganti, Srinivas [Synthetic Communications,2019,vol. 49,# 17,p. 2180 - 2187]

79887-16-4 Synthesis