N,N-dimethyl-4-methoxyphenylethylamine synthesis
- Product Name:N,N-dimethyl-4-methoxyphenylethylamine
- CAS Number:775-33-7
- Molecular formula:C11H17NO
- Molecular Weight:179.26
702-23-8
151 suppliers
$9.00/5g
124-40-3
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$18.00/100ml
775-33-7
51 suppliers
$40.00/25 mg
Yield:775-33-7 55%
Reaction Conditions:
in tetrahydrofuran at 20; for 18 h;
Steps:
A solution of 3-(4-methoxyphenyl)-1-ethanol (0.30 g, 1.39 mmol) and dimethylamine solution (2.0 M in THF, 2 mL, 4.00 mmol) was stirred in a sealed-tube at rt for 18 hr. The reaction was concentrated in vacuo. Purification by flash chromatography on silica (10% methanol in dichloromethane) afforded the titled compound as a white solid (155 mg, 55%).1H NMR (300 MHz; CDCl3) 2.67 (6H, s), 2.99 (4H, m), 3.83 (3H, s), 6.75 (2H, d, J 8.6 Hz, Ph-H), 7.08 (2H, d, J 8.6 Hz, Ph-H);13C NMR (75.5 MHz; CDCl3) 30.7, 43.6, 55.3, 59.7, 114.2, 128.6, 129.7, 158.6;m/z (+ES) 180 (100, MH+).
References:
Woscholski, Rudiger;Hailes, Helen;Numbere, Macba;Rosivatz, Erika US2009/221702, 2009, A1 Location in patent:Page/Page column 11
93413-76-4
241 suppliers
$22.00/100mg
124-40-3
500 suppliers
$18.00/100ml
775-33-7
51 suppliers
$40.00/25 mg
93413-69-5
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$10.00/1mg
50-00-0
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$10.00/25g
55-81-2
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$39.96/5g
775-33-7
51 suppliers
$40.00/25 mg
![[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE](/CAS/GIF/4091-50-3.gif)
4091-50-3
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$45.00/1g
104-47-2
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$6.00/10g
124-40-3
500 suppliers
$18.00/100ml
775-33-7
51 suppliers
$40.00/25 mg