ChemicalBook CAS DataBase List N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE

N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE synthesis

11synthesis methods

Product Name:N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE
CAS Number:3070-86-8
Molecular formula:C16H16N2O3
Molecular Weight:284.31

108-24-7
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$14.00/250ML

101-80-4 Synthesis

101-80-4
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$6.00/25g

3070-86-8
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$54.00/100mg

Yield: 98%

Reaction Conditions:

in acetone at 0;

Steps:

1.2. General Procedure for the Synthesis of Substituted Compounds 8-15
To a stirred acetone (50 ml) solution of 4, 4′-diaminodiphenyl ether (2) (5.0 g, 19.6 mmol) at 0 °C, acetic anhydride (10.0 ml, 105.8 mmol) was added dropwise and reaction had been carried out for 3 h. The reaction was monitored by TLC. After stopping the reaction, triethylamine (25 ml, 179.4 mmol) was added dropwise, neutralizing the solution, to give a white solid, filtrated, washed with acetone, and dried to obtain the compound 3.

References:

Wang, Xiu-Jun;Chu, Na-Ying;Wang, Qin-He;Liu, Chao;Jiang, Chun-Guo;Wang, Xiao-Yu;Ikejima, Takashi;Cheng, Mao-Sheng [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 19,p. 6297 - 6300] Location in patent:supporting information