ChemicalBook CAS DataBase List (S)-TETRAHYDRO-2H-PYRAN-3-OL

(S)-TETRAHYDRO-2H-PYRAN-3-OL synthesis

5synthesis methods

Product Name:(S)-TETRAHYDRO-2H-PYRAN-3-OL
CAS Number:72886-97-6
Molecular formula:C5H10O2
Molecular Weight:102.13

56-86-0 Synthesis

56-86-0
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72886-97-6
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$45.00/10mg

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / 18 h / -5 - 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere; Reflux
2.1: silver(l) oxide / ethyl acetate / 72 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / diethyl ether / 24 h / 0 - 20 °C / Inert atmosphere
4.1: triethylamine; dmap; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / 25 °C / Inert atmosphere
5.1: palladium(II) hydroxide; hydrogen / methanol / 20 h / 40 °C

References:

Geng, Yang;Zheng, Maolin;Li, Jingya;Zou, Dapeng;Wu, Yusheng;Wu, Yangjie [Tetrahedron Letters,2017,vol. 58,# 42,p. 3966 - 3969]

55094-97-8 Synthesis