ChemicalBook CAS DataBase List tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate synthesis

13synthesis methods

Product Name:tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
CAS Number:114772-40-6
Molecular formula:C18H19BrO2
Molecular Weight:347.25

TERT-BUTYL 4'-METHYLBIPHENYL-2-CARBOXYLATE

114772-36-0
44 suppliers
$90.00/10mg

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

114772-40-6
196 suppliers
$7.00/1g

Yield:114772-40-6 85%

Reaction Conditions:

with azobisisobutyronitrile;sodium acetate in acetic acid methyl ester;water;isopropyl alcohol;acetone

Steps:

4 EXAMPLE 4
EXAMPLE 4 268.0 kg of tert-butyl 4-methylbiphenyl-2'-carboxylate, 157.3 kg of DDH, 1.6 kg of AIBN, and 572 liters of methyl acetate are placed in a 1200-liter enamel stirring apparatus and the mixture is heated to 60° C. to 65° C. As soon as the solution has become practically colorless, 458 liters of solvent are distilled off under normal pressure and then 530 liters of isopropanol, 148 liters of water, and 16.4 kg of sodium acetate (anhydrous) are added. The resulting mixture is cooled to 15° C. to 25° C. and stirred for a further 1 hour. The product precipitated is separated by centrifugation, washed with a mixture of 530 liters of acetone and 148 liters of water, and dried. Yield: 295 kg of tert-butyl 4-bromomethylbiphenyl-2'-carboxylate (85% of theory).

References:

Schneider, Heinrich;Schneider, Margarete US2002/95042, 2002, A1

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55666-42-7 Synthesis