Why did the FDA reject approval of Bardoxolone methyl for chronic kidney disease?
On 25 February 2022, the FDA announced that it could not approve a New Drug Application (NDA) for Bardoxolone methyl for the treatment of Chronic Kidney Disease (CKD) due to Alport Syndrome.
May 7，2024 Drugs
Lithium Bis(fluorosulfonyl)imide: Role and Mechanism in Stabilizing the LiTPA Electrode
Lithium Bis(fluorosulfonyl)imide enhances lithium-ion battery performance by forming a stable SEI layer and longevity of LiTPA electrodes compared to LiPF6-based electrolytes.
May 7，2024 API
(2-Bromoethyl)benzene: Applications in Pharmaceutical Synthesis and its Synthesis Method
(2-Bromoethyl)benzene is essential in pharmaceutical synthesis, enabling the creation of potent antimicrobial compounds, and is synthesized through specific reactions.
May 7，2024 API
Is 2-hydroxyethyl methacrylate safe?
HEMA (2-hydroxyethyl methacrylate), commonly used in dentistry, was reported to induce genotoxic effects.
May 7，2024 Organic reagents
4-Bromoaniline: Overview, Metabolism and Preparation Method
4-Bromoaniline is a versatile compound used in various applications, with its metabolism in rats studied and its synthesis involving amination of Bromobenzene yielding 100% product.
May 7，2024 API
Is phthalic anhydride hazardous?
Phthalic anhydride is an organic compound with C6H4(CO)2O formula. It is the anhydride of phthalic acid. Phthalic anhydride is a principal commercial form of phthalic acid.
May 6，2024 Organic reagents
The structure of 2,6-Lutidine
2,6-Lutidine (2,6-dimethylpyridine, C7H9N),(I), is present in many complexes coordinated to a metal center.
May 6，2024 Organic reagents
Is Oleic acid a saturated or unsaturated fatty acid? And what does it do for the human body?
Oleic acid is (OA) an unsaturated fatty acid that occurs naturally in animal and vegetable oils.
May 6，2024 API
Acetaldehyde: Sources and Multiple DNA repair pathways
Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke.
May 6，2024 API
Laboratory and medical uses of Sodium dodecyl sulfate (SDS) detergent
Sodium dodecyl sulfate (SDS), also known as Sodium Lauryl Sulfate (SLS), is an anionic surfactant that functions as a detergent, emulsifier and protein denaturant.
May 6，2024 Surfactant