What is Fosfomycin?
Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces fradiae and by some Pseudomonas spp., but is now mostly obtained synthetically. It is a broad-spectrum antibiotic with bactericida
Mar 18，2022 API
Ampicillin–Sulbactam: Antimicrobial Activity, Susceptibility, Administration and Dosage, Clinical Uses etc.
Ampicillin–sulbactam (AMP/S) is a beta-lactam/beta-lactamase inhibitor that was developed to overcome the increasing resistance of various bacteria to ampicillin. AMP/S is marketed under various trad
Mar 18，2022 APIInstructions of ?Pristinamycin
?Pristinamycin is a mixture of water-insoluble pristinamycin IA (PIA, 90–97%) and pristinamycin IIA (PIIA, 3–10%), derived from S. pristinaespiralis.
Mar 18，2022 APILinezolid:U-100766
Linezolid (previously U-100766) is the first in a new class of completely synthetic antimicrobial agents, the oxazolidinones.
Mar 18，2022 APIThe first glycylcycline---Tigecycline
Tigecycline is produced by Wyeth under the trade name of Tygacils. The modification of the tetracycline nucleus led to a reduction in tetracycline-specific efflux and ribosomal protection.
Mar 18，2022 APIAmoxicillin–clavulanic acid: Clinical Uses and Toxicity
Co-amoxiclav is widely used with good cure rates to treat urinary tract infections caused by both beta-lactamase-producing and nonproducing organisms, although in the latter case there is no advantage
Mar 18，2022 API
Amoxicillin–clavulanic acid: Antimicrobial Activity, Susceptibility, Administration and Dosage etc.
Amoxicillin–clavulanic acid (co-amoxiclav) is a combination product consisting of the semisynthetic antibiotic amoxicillin with the beta-lactamase inhibitor clavulanic acid as a potassium salt.
Mar 18，2022 API
Tazobactam: Antimicrobial Activity, Susceptibility, Administration and Dosage, Clinical Uses etc.
Being a beta-lactamase inhibitor, tazobactam is synergistic with many beta-lactamaselabile drugs, such as penicillin G, ampicillin, or piperacillin against many bacterial species which produce beta-l
Mar 18，2022 InhibitorsWhat is SR9009?
SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ with IC50 values of 670 and 800 nM, respectively.
Mar 18，2022 Inhibitors
Sulbactam: Antimicrobial Activity, Susceptibility, Administration and Dosage, Clinical Uses etc.
Sulbactam sodium is a semisynthetic beta-lactamase inhibitor obtained by oxidation of the thiazolidine sulfur of penicillanic acid (English et al., 1978).
Mar 18，2022 API