ChemicalBook--->CAS DataBase List--->1276110-06-5

1276110-06-5

1276110-06-5 Structure

1276110-06-5 Structure
IdentificationMore
[Name]

HS-173
[CAS]

1276110-06-5
[Synonyms]

HS-173
ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate
6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester
6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester HS-173
[Molecular Formula]

C21H18N4O4S
[MDL Number]

MFCD28023584
[MOL File]

1276110-06-5.mol
[Molecular Weight]

422.457
Chemical PropertiesBack Directory
[Melting point ]

>193°C (dec.)
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

Chloroform (Slightly), DMSO (Slightly)
[form ]

Solid
[pka]

6.84±0.40(Predicted)
[color ]

Grey to Brown
Hazard InformationBack Directory
[Description]

HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM. It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively. HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases. It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.
[Uses]

HS-173 is a potent PI3Kα inhibitor with anticancer activity.
[in vitro]

hs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1].
[in vivo]

hs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1].
[target]

PI3Kα
[References]

[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9.
Spectrum DetailBack Directory
[Spectrum Detail]

HS-173(1276110-06-5)1HNMR
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