ChemicalBook--->CAS DataBase List--->40516-48-1

40516-48-1

40516-48-1 Structure

40516-48-1 Structure
IdentificationMore
[Name]

Tocoretinate
[CAS]

40516-48-1
[Synonyms]

3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
TOCORETINATE
tretinoin tocoferil
VITAMIN E VITAMIN A ACID ESTER
L 300
N 021
Olcenon
Retinoic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester, rel-(9CI)
Retinoic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R*(4R*,8R*)]-(+-)-
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
[Molecular Formula]

C49H76O3
[MDL Number]

MFCD00909856
[Molecular Weight]

713.13
[MOL File]

40516-48-1.mol
Chemical PropertiesBack Directory
[CAS DataBase Reference]

40516-48-1(CAS DataBase Reference)
Hazard InformationBack Directory
[Description]

Tretinoin tocoferil, the a-tocopherol ester of all-trans-retinoic acid, was launched for the treatment of bedsores and skin ulcers such as burn, leg, and diabetic ulcers. It is also an orally active agent for gastric ulcer treatment. Tretinoin tocoferil represents a new class of antiulcer drugs which act by directly promoting tissue repair, distinguished from common drugs that exert an indirect function by suppression of acid-secretion and mucosa protection. The mode of its action has been proposed to relate to its ability to stimulate DNA synthesis of growth-arrested human skin fibroblasts by promoting expression of the epidermal growth factor receptor.
[Originator]

Nisshin Flour Milling (Japan)
[Uses]

dl-α-Tocopheryl Retinoate is an α-tocopherol ester of all-trans retinoic acid (R250200) and is safely used in the treatment of skin ulcer. ?dl-α-Tocopheryl Retinoate inhibited proliferation of human promyelocytic leukemia HL-60 cells and induced granulocytic differentiation of the cells, but to a lesser extent than did retinoic acid.
[Definition]

ChEBI: Tocoretinate is a tocol.
[Brand name]

Olcenon
Safety DataBack Directory
[Toxicity]

LD50 in mice (mg/kg): >1000 i.v.; >2000 orally (Fukawa, 1975)
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