| Identification | More | [Name]
Mangiferin | [CAS]
4773-96-0 | [Synonyms]
1,3,6,7-tetrahydroxy-2-[(3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
1,3,6,7-TETRAHYDROXYXANTHONE-2-C-GLUCOSIDE
1,3,6,7-Tetrahydroxyxanthone C2-beta-D-glucoside
2-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-one
Alpizarine
MANAGIFERIN
MANGIFERN
XANTHONE-C-GLUCOSIDE
2-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-on
alpizarin
aphloiol
chinomin
chinonin
hedysarid
mangiferin from mangifera indica leaves
MANGIFERIN 98% HPLC
Mangiferin90%
Mangiferin(FrommangoBarK)
MANGIFERIN(P)
XANTHONE-C-GLUCOSIDE, FROM MANGIFERA INDICA LEAVES | [EINECS(EC#)]
624-757-7 | [Molecular Formula]
C19H18O11 | [MDL Number]
MFCD00075656 | [Molecular Weight]
422.34 | [MOL File]
4773-96-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
269-270°C | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly), Pyridine (Slightly, Heated) | [Boiling point ]
842.7±65.0 °C(Predicted) | [density ]
1.843±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.09±0.20(Predicted) | [color ]
Pale Yellow | [Stability:]
Hygroscopic | [InChIKey]
AEDDIBAIWPIIBD-AZBPZEDSNA-N | [SMILES]
OC1=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C(O)=CC2OC3=CC(O)=C(O)C=C3C(=O)C1=2 |&1:3,4,5,7,9,r| | [LogP]
0.130 (est) | [CAS DataBase Reference]
4773-96-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,Xi | [Risk Statements ]
R28:Very Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3462 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
OP1927800
| [HS Code ]
29389090 |
| Hazard Information | Back Directory | [Description]
Mangiferin is a plant natural polyphenol of C-glycosylxanthone structure and various pharmacological activities. It can be found in many plant species, among which the mango tree (Mangifera indica) is one of the primary sources. Mangiferin is also present in some medicinal herbs, influencing their therapeutic and preventive properties, and in honeybush (Cyclopia sp.), a popular South African herbal tea. Mangiferin dissolves well in water, so it can be easily extracted into infusions and decoctions. In the mangiferin molecule, four aromatic hydroxyl groups determine its strong antiradical and antioxidant properties. Mangiferin is also an efficient iron chelator, therefore preventing the generation of hydroxyl radicals in Fenton-type reactions[1].
| [Chemical Properties]
Yellow powder | [Uses]
Mangiferin is a xanthonoid, a chemical compound found in mangoes and in Anemarrhena asphodeloides rhizomes. Mangiferin has effect of hepatinica and choleretic, and is used to therapy hepatitis. Mangif
erin is an anti-inflammatory, antivirotic, central nervous system inhibit function and immunologic suppression.
Mangiferin has curative effect on chronic bronchitis. Mangiferin has cytotoxicity effec
t on hepatocellular
carcinoma ce1l, and may induce apoptosis. Mangiferin has the effect of antioxidation and delaying caducity. | [Uses]
MAO inhibitor, immunostimulant | [Definition]
ChEBI: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position. | [General Description]
Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs. | [Biochem/physiol Actions]
Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic properties in streptozotocin-induced diabetic rats. MGF exerts chemotherapeutic and chemo-preventative activities. It displays antioxidant, analgesic, and hepatoprotective activity against carbon tetrachloride-induced liver injury. MGF is a known accelerator of gastrointestinal transit (GIT). | [References]
[1] Adam Matkowski. “Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant.” Mini reviews in medicinal chemistry 13 3 (2013): 439–55.
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