Identification | More | [Name]
6-Bromoquinoline | [CAS]
5332-25-2 | [Synonyms]
6-BROMOQUINOLINE TIMTEC-BB SBB001559 6-bromo-quinolin Quinoline, 6-bromo- 6-BROMOQUINOLINE 95+% 6-BROMOOQUINOLINE 6-Bromoquinoline ,98% | [EINECS(EC#)]
206-363-3 | [Molecular Formula]
C9H6BrN | [MDL Number]
MFCD00024023 | [Molecular Weight]
208.05 | [MOL File]
5332-25-2.mol |
Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R22:Harmful if swallowed. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S37/39:Wear suitable gloves and eye/face protection . S39:Wear eye/face protection . S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29334900 |
Hazard Information | Back Directory | [Chemical Properties]
Thick Oil | [Uses]
6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent. |
Questions And Answer | Back Directory | [Bromoquinoline]
There are seven positional isomers of bromoquinoline and their main properties are listed below:
| [Application and synthetic method]
3-bromo-quinoline is reacted with mixed acid for generating 3-bromo-5-nitro-quinoline, which heats together with potassium permanganate for being oxidation into 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline is heated together with nitric acid to generate 6-bromo-8-nitro quinolone with further reaction with potassium permanganate for being oxidized to 2, 3-pyridinedicarboxylic acid.
2-bromo-quinolien can be synthesized through the reaction between 2-hydroxy quinoline and phosphorus pentabromide.
Quinoline perbromide is heated at 180 °C for generating 3-bromo-quinoline.
From the heating between 4-hydroxy quinoline and phosphorus pentabromide, or from the diazotization reaction via 4-aminoquinoline to generate 4-bromo-quinoline;
5-bromo-quinoline is synthesize by the heating reaction between m-bromo-aniline, glycerol, m-bromo nitrobenzene and concentrated sulfuric acid, or from the diazotization reaction of 5-aminoquinoline.
6-bromo-quinoline can be synthesized from the heating of bromoaniline, glycerol, concentrated sulfuric acid, and p-bromo-nitrobenzene.
7-bromo-quinoline can be synthesized from the diazotization reaction of 7-aminoquinoline.
8-bromo-quinoline can be synthesized from the heating reaction of o-bromo-aniline, glycerol, concentrated sulfuric acid and o-bromo nitrobenzene.
application: as organic synthesis reagents.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
|
|
|