| Identification | Back Directory | [Name]
CATHEPSIN D | [CAS]
9025-26-7 | [Synonyms]
CATHEPSIN D
EC 3.4.22.5
EC 3.4.23.5
Cathepsins D
CATHEPSIN D, HUMAN
CATHEPSIN D, BOVINE
CATHEPSIN D, HUMAN LIVER
Native Human Cathepsin D
Native Bovine Cathepsin D
CATHEPSIN D, HUMAN SPLEEN
CATHEPSIN D, BOVINE KIDNEY
CATHEPSIN D, BOVINE SPLEEN
CATHEPSIN D, FROM HUMAN LIVER
CATHEPSIN D FROM BOVINE SPLEEN
Cathepsin D from Human, recombinant | [Molecular Formula]
NULL | [MDL Number]
MFCD02662346 |
| Hazard Information | Back Directory | [Uses]
Cathepsin D from human liver has been used:
- in β-secretase activity assay
- for enzymatic degradation of amyloid β 1-42
- in microinjection of human foreskin fibroblasts
| [Uses]
Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer. | [General Description]
Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis. | [Biochem/physiol Actions]
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. | [Purification Methods]
Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960]. |
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