18422-05-4
![18422-05-4 结构式](/CAS/GIF/18422-05-4.gif)
基本信息
腺苷-5'-磷酸
腺苷-5'-单磷酸一水合物
腺苷-5'-磷酸(一水)
5-ADENYLIC ACID
5'-AMP H2O
5'-AMP MONOHYDRATE
A-5'-P
ADENOSINE 5'-MONOPHOSPHATE
ADENOSINE 5'-MONOPHOSPHATE MONOHYDRATE
ADENOSINE 5'-MONOPHOSPHORIC ACID MONOHYDRATE
ADENYLIC ACID MONOHYDRATE
AMP
ADENOSINE 5'-MONOPHOSPHATE FREE ACID97+% FROM YEAS
5'-AMP=Adenylicacid
ADENOSINE-5'-MONOPHOSPHATE 1-HYDRATE
5-Adenylic acid, monohydrate
Adenosine-5''-monophosphoric acid (and/or unspecified salts)
5'-AMP
Adenosine-5'-monophosphoric acid monohydrate >96%
AMP monohydrate
5μ-AMP, Adenylic acid from muscle, AMP
5μ-Adenylic acid, 5μ-AMP, A-5μ-P, AMP
物理化学性质
安全数据
常见问题列表
Adenosine A 1 receptor
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells. Adenosine 5'-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400 μM, Adenosine 5'-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5'-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters.
C57BL/6J mice treated with Adenosine 5'-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8 h) and 33.3% (24 h), whereas survival rate in Adenosine 5'-monophosphate monohydrate-treated mice (n=15) is 100% (8 h) and 93.3% (24 h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5'-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5'-monophosphate monohydrate group.
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-A0181A | 腺苷-5'-单磷酸一水合物 Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 500mg | 400元 |
2024/08/19 | HY-A0181A | 腺苷-5'-单磷酸一水合物 Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 10mM * 1mLin Water | 500元 |
2024/08/19 | HY-A0181A | 腺苷-5'-单磷酸一水合物 Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 1g | 500元 |