22246-18-0
中文名称
3,4-二氢-7-羟基-2(1H)-喹啉酮
英文名称
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
CAS
22246-18-0
分子式
C9H9NO2
MDL 编号
MFCD06410891
分子量
163.17
MOL 文件
22246-18-0.mol
更新日期
2024/08/19 09:27:44
![22246-18-0 结构式](/CAS/GIF/22246-18-0.gif)
基本信息
中文别名
7-羟基-3,4-二氢-2(1H)-喹啉酮7-羟基-2(1H)-3,4-二氢喹啉酮
3,4-二氢-7-羟基-2(1H)-喹啉酮
7-羟基-3,4-二氢喹诺酮
3,4-二氢-7-羟基2(1H)-喹诺酮
英文别名
(1H)-7-HYDROXY-3,4-DIHYDRO-2-QUINOLINONE3,4-DIHYDRO-7-HYDROXYCARBOSTYRIL
7-HYDROXY-1,2,3,4-TETRAHYDRO-2-QUINOLINONE
7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE
7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLINE-2-ONE
7-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
7-HYDROXY-3,4-DIHYDRO-2-OXO-(1H)-QUINOLINE
7-HYDROXY-3,4-DIHYDROCARBOSTYRIL
7-HYDROXY-3,4-DIHYDRO CARBOSTYRYL
7-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE
7-HYDROXY-3,4-DIHYDRO-QUINOLIN-2-ONE
8-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
AURORA KA-4813
7-Hydroxy-2(1H)-3,4-dihydroquinolinone
7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE3,4-DIHYDRO-7-HYDROXY-2-(1H)-QUINOLINONE
3,4-Dihydro-7-Hydroxy-2(1H)-Quinlinone
7-Hydroxy-2-Oxo-3,4-Dihydroquinoline
7-Hydroxy-3,4-dihydro-2(1H)-qu
3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINONE /7-HQ
所属类别
医药中间体:喹啉类化合物物理化学性质
熔点233-237 °C
沸点403.7±45.0 °C(Predicted)
密度1.282±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Room Temperature
溶解度可溶于DMSO(少许)、甲醇(少许)
酸度系数(pKa)9.60±0.20(Predicted)
形态固体
颜色淡黄色
InChIKeyLKLSFDWYIBUGNT-UHFFFAOYSA-N
常见问题列表
制备
(1)3-氯-N-(3-羟基苯基)丙酰胺
把20mmol间氨基酚溶于二氯甲烷中,滴加20mmol三乙胺,室温搅拌下滴加22mmol3-氯丙酰氯,滴毕,室温搅拌10h。去离子水洗涤三次,有机相用柱层析分离,得到68%的3-氯-N-(3-羟基苯基)丙酰胺。
(2) 3,4-二氢-7-羟基-2(1H)-喹啉酮
把10mmol3-氯-N-(3-羟基苯基)丙酰胺、40mmol三氯化铝和6mmolN,N-二甲基乙酰胺置于三口烧瓶中,150℃反应5小时,缓慢滴加20mL冰水冷却,继续加热至90℃搅拌1小时,冷却至室温,过滤得到红色固体,柱层析得到88%的3,4-二氢-7-羟基-2(1H)-喹啉酮。
用途
3,4-二氢-7-羟基-2(1H)-喹啉酮可用于有机合成,医药合成中间体,可用于合成阿立哌唑。生物活性
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) 是一种弱 MAO-A 抑制剂,IC50 值为 183 μM,对 MAO-B 无作用。靶点
IC50: 183 μM (MAO-A)
体外研究
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.