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23642-66-2

中文名称 盐酸苯氟雷司
英文名称 BENFLUOREX HYDROCHLORIDE
CAS 23642-66-2
分子式 C19H21ClF3NO2
分子量 387.82
MOL 文件 23642-66-2.mol
更新日期 2024/12/17 09:24:29
23642-66-2 结构式 23642-66-2 结构式

基本信息

中文别名
盐酸苯氟雷司
N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯
2-((1-(3-(三氟甲基)苯基)丙烷-2-基)氨基)乙基苯酸盐盐酸
英文别名
Balans
mediator
LT00134683
Lipophoral
Einecs 245-801-8
LABOTEST-BB LT00134683
BENFLUOREX HYDROCHLORIDE
2-(alpha-Methyl-3-(trifluoromethyl)phenylethylamino)ethyl benzoat
2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est
2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est
所属类别
分析化学:分析标准品

物理化学性质

熔点158-159?C
储存条件Refrigerator
溶解度氯仿(微溶)、甲醇(微溶)、水(微溶)
形态neat
颜色白色

安全数据

危险性符号(GHS)GHS hazard pictograms
GHS07
警示词警告
危险性描述H315-H335-H319
危险品标志Xi
WGK Germany2
RTECS号KL8275000
Hazard NoteIrritant
海关编码2916399090
毒性LD50 intraperitoneal in mouse: 108mg/kg
盐酸苯氟雷司价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/11/08HY-B1058盐酸苯氟雷司
Benfluorex hydrochloride
23642-66-2500 mg350元
2024/11/08HY-B1058盐酸苯氟雷司
Benfluorex hydrochloride
23642-66-210mM * 1mLin DMSO550元
2022/07/01HY-B1058盐酸苯氟雷司
Benfluorex hydrochloride
23642-66-2100mg500元

常见问题列表

生物活性
Benfluorex hydrochloride (JP-992 hydrochloride) 是一个肝核因子 4α (HNF4α) 激活剂。
靶点

HNF4α

体外研究

Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression. Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not. Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of 14 CO 2 into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).

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