54472-66-1
中文名称
AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT
英文名称
AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT
CAS
54472-66-1
分子式
C78H108N18O21S2
分子量
1697.95
MOL 文件
54472-66-1.mol
54472-66-1 结构式
基本信息
英文别名
GHIHSomatostatin monoacetate
SOMATOSTATIN 14, ACETATE
AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT
H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (DISULFIDE BRIDGE: 3-14), ACETATE SALT
应用领域
用途一
Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin. It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant receptors). It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively). Somatostatin-14 inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules.