网站主页 >> CAS数据库列表 >> [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
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- CAS号:
- 164083-84-5
- 英文名:
- LY311727
- 英文别名:
- LY 311727;3-(1-Benzyl-2-ethyl-3-carboxamido-methyl-indol-5-yl)-oxy-propan-ephosphonic acid;(3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid;[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid;(3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid (ApexBio);Phosphonic acid, P-[3-[[3-(2-aMino-2-oxoethyl)-2-ethyl-1-(phenylMethyl)-1H-indol-5-yl]oxy]propyl]-
- 中文名:
- [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
- 中文别名:
- 化合物 T22950;(3-((3-(2-氨基-2-氧代乙基)-1-苄基-2-乙基-1H-吲哚-5-基)氧基)丙基)膦酸
- CBNumber:
- CB02518822
- 分子式:
- C22H27N2O5P
- 分子量:
- 430.43
- MOL File:
- 164083-84-5.mol
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[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid化学性质
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沸点:
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758.2±70.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥15mg/mL
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酸度系数(pKa):
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2.43±0.10(Predicted)
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形态:
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powder
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颜色:
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white to tan
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[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid性质、用途与生产工艺
分泌型磷脂酶 A2 (sPLA2) 异构体是低分子量、毫摩尔量的钙依赖性酶，可从膜磷脂的 sn-2 位水解脂肪酸。IIA 组 sPLA2，也称为 sPLA2IIA 和非胰腺 sPLA2，具有调节类花生酸合成的作用，并可能调节炎症信号传导。LY311727 是 IIA 组 sPLA2 (IC50 = 0.47 μM) 的抑制剂，以非共价方式与酶的活性位点相互作用。它显示出比胰腺 sPLA2（IB 组 sPLA2）高 1,500 倍以上的选择性。LY311727通常用于区分 IIA 组 sPLA2 与生物系统中其他 sPLA2 同种型的作用。
LY-311727 是一种分泌型磷脂酶 A2 (sPLA2) 抑制剂 (IC50 <1 μM for group IIA sPLA2)。sPLA2 是一种重要的促炎症酶。
LY-311727 (0.1-10 μM) suppresses the contractile responses induced by human non-pancreatic secretory phospholipase A
2
(hnps-PLA
2
), in a concentration related manner.
LY-311727 nearly abolishes the hnps-PLA
2
responses at 1μM, while it failed to suppress porcine pancreatic PLA
2
concentration response curves at the same concentration.
LY-311727 displays 1,500-fold selectivity when assayed against porcine pancreatic s-PLA
2
.
LY-311727 (3-30 mg/kg; i.v.) dramatically suppresses the circulating enzyme activity in mice with Mt-sPLA
2
transgenic the intravenous (i.v.) administration.
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Animal Model:
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C57BL/6J mice, metallothionein promoter-human secretory PLA
2
minigene (Mt-sPLA
2
) transgenic mice model
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Dosage:
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3 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:
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Intravenous injection
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Result:
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Significantly and dose dependently suppressed the PLA
2
activity in the serum.
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[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-107393 | [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
LY-311727 | 164083-84-5 | 5mg | 2800元 |
[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid
生产厂家
164083-84-5, [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid 相关搜索:
- C22H27N2O5P
- (3-((3-(2-氨基-2-氧代乙基)-1-苄基-2-乙基-1H-吲哚-5-基)氧基)丙基)膦酸
- 化合物 T22950
- 164083-84-5
- 3-(1-Benzyl-2-ethyl-3-carboxamido-methyl-indol-5-yl)-oxy-propan-ephosphonic acid
- (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid (ApexBio)
- (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid
- Phosphonic acid, P-[3-[[3-(2-aMino-2-oxoethyl)-2-ethyl-1-(phenylMethyl)-1H-indol-5-yl]oxy]propyl]-
- LY 311727
- [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid