P11
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- CAS号:
- 848644-86-0
- 英文名:
- P11
- 英文别名:
- P11 ( (trifluoroacetate salt);L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI)
- 中文名:
- P11
- 中文别名:
- 抑制剂多肽P11;HSDVHK-NH2;H-HIS-SER-ASP-VAL-HIS-LYS-NH2
- CBNumber:
- CB04796587
- 分子式:
- C30H48N12O9
- 分子量:
- 720.79
- MOL File:
- 848644-86-0.mol
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P11化学性质
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沸点:
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1380.0±65.0 °C(Predicted)
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密度:
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1.381±0.06 g/cm3(Predicted)
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储存条件:
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-20°C, protect from light
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溶解度:
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Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
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形态:
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Powder
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酸度系数(pKa):
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4.17±0.10(Predicted)
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颜色:
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White to off-white
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序列:
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H-His-Ser-Asp-Val-His-Lys-NH2
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P11性质、用途与生产工艺
HSDVHK-NH2 是整合素 αvβ3-玻璃体结合蛋白的互作抑制剂，其 IC50 值为 1.74 pg/mL (2.414 pM)。
HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group.
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC
50
value of 25.72 nM.
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression.
Cell Proliferation Assay
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Cell Line:
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HUVEC cells.
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Concentration:
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0.1, 1, 10, and 100 μg/mL.
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Incubation Time:
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72 h.
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Result:
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Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
P11
上下游产品信息
上游原料
下游产品
848644-86-0, P11 相关搜索:
- 目录肽
- C30H48N12O9
- 抑制剂多肽P11
- H-HIS-SER-ASP-VAL-HIS-LYS-NH2
- HSDVHK-NH2
- 848644-86-0
- P11 ( (trifluoroacetate salt)
- L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI)